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- 详细信息
- 文献和实验
- 技术资料
- 库存：
大量
- 英文名：
Alexa Fluor® 488 anti-mouse Galectin-9 Antibody
- CAS号：
Alexa Fluor® 488 anti-mouse Galectin-9 Antibody
- 保质期：
详见说明
- 供应商：
齐源生物
- 保存条件：
2-8℃
- 规格：
25 ug/ 100 ug
| 规格： | 25 ug | 产品价格： | ￥2700.0 |
|---|---|---|---|
| 规格： | 100 ug | 产品价格： | ￥6300.0 |
Description：
Galectin-9 is a mammalian lectin with a molecular weight of 40 kD that has two conserved carbohydrate recognition domains (CRDs) and forms homodimers. It recognizes N-acetyllactosamine (Galbeta1-4GlcNAc) and T-antigen (Galbeta1-3GalNAc); Tim-3 has been reported as its ligand. Galectin-9 is expressed by lymphocytes, dendritic cells, granulocytes, eosinophils, astrocytes, endothelial cells, fibroblasts and thymus epithelial cells. It may be retained intracellularly or be transported to the cell surface where it is cleaved, thereby generating a soluble form. Galectin-9 is involved in events such as cell aggregation, cell adhesion, chemotaxis and apoptosis. Importantly for the regulation of the immune response, Galectin-9 induces regulatory T cells and suppresses Th1 and Th17 responses.
Other Names：Lgals9, Gal-9, Ecalectin
Isotype：Rat IgG2a, κ
Reactivity：Mouse
Antibody Type：Monoclonal
Host Species：Rat
Immunogen：Full length recombinant mouse Galectin-9 (M-type)
Formulation：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation：The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
Concentration：0.5 mg/ml
Storage & Handling：The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application：
IHC-F - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
Excitation Laser：Blue Laser (488 nm)
Application Notes：
Clone 108A2 recognizes the linker peptide of mouse Galectin-9; it does not cross-react with stable Galectin-9 (which is biologically active, genetically engineered, linker-less Galectin-9)3. Additional reported applications (for the relevant formats) include: sandwich ELISA as capture antibody1 and immunohistochemical staining of paraffin2 embedded tissue sections.
Application References：
Tsuboi Y, et al. 2007. Clin. Immunol. 124:221. (ELISA)
Personal communication. (IHC-Paraffin)
Oomizu S, et al. 2012. PLoS One. 7:e48574. PubMed
Madireddi S, et al. 2014. J Exp Med. 211:1433. PubMed
Structure：Homodimer, each chain is a 343 aa protein of 40 kD that has two conserved carbohydrate recognition domains (CRDs)
Distribution：Lymphocytes, dendritic cells, neutrophils, eosinophils, astrocytes, endothelial cells, fibroblasts, thymus stromal/epithelial cells
Function：Cell aggregation, cell adhesion, chemotaxis, apoptosis, suppression of Th1 and Th17 responses, induction of regulatory T cells
Ligand/Receptor：Tim-3
Cell Type：Astrocytes, Dendritic cells, Endothelial cells, Eosinophils, Epithelial cells, Fibroblasts, Lymphocytes, Neutrophils, Tregs
Biology Area：Apoptosis/Tumor Suppressors/Cell Death, Cell Adhesion, Cell Biology, Cell Motility/Cytoskeleton/Structure, Immunology
Molecular Family：Adhesion Molecules, Immune Checkpoint Receptors
Antigen References：
1. Klibi J, et al. 2009. Blood 113:1957.
2. Seki M, et al. 2008. Clin. Immunol. 127:78.
3. Tsuboi Y, et al. 2007. Clin. Immunol. 124:221.
4. Zhu C, et al. 2005. Nat. Immunol. 6:1245.
5. Dunphy JL, et al. 2002. J. Biol. Chem. 277:14916.
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文献和实验常用抗体标记荧光染料的选择 随着免疫荧光技术的不断发展，荧光染料及其标记的抗体偶联物也被广泛的应用于生物学实验中。目前，市场上抗体及蛋白标记的荧光染料主要有CFTM系列(BIOTIUM, USA); Alexa Fluor®系列 (Life technology, USA); DyLight系列;Cy系列; IR Dye系列等等。使用最多的为AlexaFluor®系列和CFTM系列。CFTM系列染料的核心对比AlexaFluor®系列具有以下几点优势：1. 新型罗丹明核心罗丹明染料以优异
随着免疫荧光技术的不断发展，荧光染料及其标记的抗体偶联物也被广泛的应用于生物学实验中。目前，市场上抗体及蛋白标记的荧光染料主要有CFTM系列(BIOTIUM, USA); Alexa Fluor®系列(Life technology, USA); DyLight系列; Cy系列; IR Dye系列等等。使用最多的为Alexa Fluor®系列和CFTM系列。一、CFTM系列染料的核心对比Alexa Fluor®系列具有以下几点优势：1、新型罗丹明核心罗丹明染料以优异的耐光性和良好的荧
随着免疫荧光技术的不断发展，荧光染料及其标记的抗体偶联物也被广泛的应用于生物学实验中。目前，市场上抗体及蛋白标记的荧光染料主要有CFTM系列(BIOTIUM, USA); Alexa Fluor®系列(Life technology, USA); DyLight系列; Cy系列; IR Dye系列等等。使用最多的为Alexa Fluor®系列和CFTM系列。 一、CFTM系列染料的核心对比Alexa Fluor®系列具有以下几点优势： 1、新型罗丹明核心 罗丹明染料以优异
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