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- 技术资料
- 库存：
99
- 英文名：
APC anti-mouse CD107a (LAMP-1)
- 供应商：
北京云肽生物科技有限公司
BioLegend 121614 APC anti-mouse CD107a (LAMP-1)
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国BioLegend公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend虽然成立的时间不长，但它聚集了一批来自PharMingen公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。BioLegend公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 121614 APC anti-mouse CD107a (LAMP-1)
产品简介：
产品品牌：BioLegend
产品货号：121614
产品名称：BioLegend 121614 APC anti-mouse CD107a (LAMP-1)
产品规格：100 µg
产品说明：
Clone D4B (See other available formats)
Regulatory Status RUO
Other Names
Lysosome-associated membrane glycoprotein 1, lysosomal membrane glycoprotein 1, CD107 antigen-like family member A, lysosome-associated membrane protein 1
Isotype Rat IgG2a, κ
描述
CD107a，也称为溶酶体相关膜蛋白1（LAMP-1）或LGP-120，是一种110-140kD的I型膜糖蛋白。成熟的CD107a从40kD核心蛋白高度糖基化。该分子位于溶酶体的管腔侧。活化后，CD107a转移到活化的血小板、活化的淋巴细胞、巨噬细胞、上皮细胞、内皮细胞和一些肿瘤细胞的细胞膜表面。CD107a被认为在保护溶酶体膜免受溶酶体水解酶的影响中发挥作用，溶酶体水解酶参与细胞粘附和肿瘤转移的调节，并介导自身免疫性疾病的进展。CD107a是半乳肽和E-选择素的配体。LAMP-1的表面表达已被证明与CD8+T细胞和NK细胞的细胞毒性相关。
CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.
Product Details
Isotype Control APC Rat IgG2a, κ Isotype Ctrl
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen This monoclonal antibody was raised against NIH/3T3 mouse embryonic fibroblast tissue culture cell membranes. It has been mapped to the N-terminus of LAMP-1.
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration 0.2 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser ed Laser (633 nm)
Antigen Details
Structure LAMP-1 is a 406 amino acid protein with a molecular mass of 44 kD.
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BioLegend 121614 APC anti-mouse CD107a (LAMP-1)
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