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- 技术资料
- 库存：
99
- 英文名：
APC anti-mouse CD204
- 供应商：
北京云肽生物科技有限公司
BioLegend 154711 APC anti-mouse CD204
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国BioLegend公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend虽然成立的时间不长，但它聚集了一批来自PharMingen公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。BioLegend公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 154711 APC anti-mouse CD204
产品简介：
产品品牌：BioLegend
产品货号：154711
产品名称：BioLegend 154711 APC anti-mouse CD204
产品规格：25 µg
产品说明：
Clone 1F8C33 (See other available formats)
Regulatory Status RUO
Other Names
Msr1, MSR, SR-A, Scavenger receptor type A, Macrophage scavenger receptor I, Scara1
Isotype Rat IgG2a, κ
描述
CD204，也称为清道夫受体A（SR-A）和巨噬细胞清道夫受体（MSR），是220kDa，三聚体II型跨膜蛋白，具有一个清道夫受体富含半胱氨酸结构域（SRCR）。它是巨噬细胞和树突状细胞上表达的吞噬模式识别受体（PRR）。CD204是一种介导巨噬细胞识别和内化低密度脂蛋白（LDL）的受体，在动脉粥样硬化形成中起着关键作用。CD204还识别凋亡细胞、修饰的脂质蛋白和外源性病原体相关分子模式（PAMP），从而诱导先天免疫和炎症反应。CD204可以作为Toll样受体（如TLR3、TLR4或TLR9）的共受体，以促进促炎细胞因子的表达。CD204与阿尔茨海默病、败血症、缺血性损伤和冠状动脉疾病等多种病理过程有关。
CD204, also known as scavenger receptor A (SR-A) and the macrophage scavenger receptor (MSR), is 220 kDa, trimeric type II transmembrane protein, with one scavenger receptor cysteine-rich domain (SRCR). It is a phagocytic pattern-recognition receptor (PRR) expressed on macrophages and dendritic cells. CD204 is a receptor mediating recognition and internalization of low-density lipoprotein (LDL) by macrophages and plays a critical role in atherogenesis. CD204 also recognizes apoptotic cells, modified lipid proteins, and exogenous pathogen-associated molecular patterns (PAMPs), which results in the induction of innate immune and inflammatory responses. CD204 can act as a co-receptor for Toll-like receptors, such as TLR3, TLR4, or TLR9, to facilitate the expression of proinflammatory cytokines. CD204 has been implicated in several pathological processes such as Alzheimer’s disease, sepsis, ischemic injury, and coronary artery disease.
Product Details
Isotype Control APC Rat IgG2a, κ Isotype Ctrl
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen
Recombinant mouse CD204 extracellular domainFormulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser Red Laser (633 nm)
Antigen Details
Structure
Trimeric type II transmembrane protein, one scavenger receptor cysteine-rich domain (SRCR), 220 kD.
Distribution Macrophages, dendritic cells.
Function
Uptake of negatively charged molecules, role in pathology of atherosclerosis and Alzheimer’s disease.
Ligand/Receptor
Acetylated and oxidized lipoproteins
Cell Type Dendritic cells, Macrophages
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BioLegend 154711 APC anti-mouse CD204
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