产品说明: Clone OX-86 (See other available formats) Regulatory Status RUO Other Names TNFRSF4, ACT35, OX-40 Isotype Rat IgG1, κ
描述 CD134是一种I型整合膜蛋白,也称为OX-40、ACT35和肿瘤坏死因子受体超家族成员4(TNFRSF4)。该受体在活化的CD4+和CD8+T细胞以及B细胞上表达。OX-40受体与OX-40配体(CD252)结合以提供独立于CD28的共刺激信号。阻断OX40-OX40配体相互作用已被证明可以改善实验性EAE和炎症性肠病,这意味着这些相互作用在某些自身免疫性疾病的发病机制中很重要。 CD134 is a type I integral membrane protein also known as OX-40, ACT35, and tumor necrosis factor receptor superfamily member 4 (TNFRSF4). This receptor is expressed on activated CD4+ and CD8+ T cells and B cells. The OX-40 receptor binds to the OX-40 ligand (CD252) to provide a costimulatory signal that is independent of CD28. Blockade of OX40-OX40 ligand interactions has been shown to ameliorate experimental EAE and inflammatory bowel disease, which implies that these interactions are important in the pathogenesis of some autoimmune diseases.
Product Details Isotype Control PE/Cyanine7 Rat IgG1, κ Isotype Ctrl Verified Reactivity Mouse Antibody Type Monoclonal Host Species Rat Immunogen Recombinant mouse OX-40-CD4 chimeric protein Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Preparation The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions. Concentration 0.2 mg/ml Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application FC - Quality tested Recommended Usage Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application. Excitation Laser Blue Laser (488 nm) Green Laser (532 nm)/Yellow-Green Laser (561 nm) Application Notes Clone OX-86 has been reported to act as an agonist and stimulate OX-40. Additional Product Notes BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
Antigen Details Structure TNF receptor superfamily, 50 kD Distribution Activated CD4+ and CD8+ T cells, activated B cells.
Function Receptor for OX-40 ligand, provides co-stimulatory signal for lymphocyte proliferation independent of CD28; thought to play a role in the pathogenesis of some autoimmune diseases Ligand/Receptor OX-40 ligand Cell Type B cells, T cells, Tregs Biology Area Immunology Molecular Family CD Molecules, Immune Checkpoint Receptors
以下是BioLegend 品牌部分产品,如需其他产品请联系本公司销售。 BioLegend 104317 PE/Cyanine7 anti-mouse/rat CD61 2C9.G2 (HMβ3-1) 25 ug BioLegend 104318 PE/Cyanine7 anti-mouse/rat CD61 2C9.G2 (HMβ3-1) 100 ug BioLegend 104406 FITC anti-mouse CD62L MEL-14 500 ug BioLegend 104407 PE anti-mouse CD62L MEL-14 50 ug BioLegend 104408 PE anti-mouse CD62L MEL-14 200 ug BioLegend 104410 PE/Cyanine5 anti-mouse CD62L MEL-14 100 ug BioLegend 104411 APC anti-mouse CD62L MEL-14 25 ug BioLegend 104412 APC anti-mouse CD62L MEL-14 100 ug BioLegend 104419 Alexa Fluor® 488 anti-mouse CD62L MEL-14 25 ug BioLegend 104420 Alexa Fluor® 488 anti-mouse CD62L MEL-14 100 ug BioLegend 104421 Alexa Fluor® 647 anti-mouse CD62L MEL-14 25 ug BioLegend 104423 Pacific Blue™ anti-mouse CD62L MEL-14 25 ug BioLegend 104424 Pacific Blue™ anti-mouse CD62L MEL-14 100 ug BioLegend 104426 Alexa Fluor® 700 anti-mouse CD62L MEL-14 100 ug BioLegend 104429 PerCP anti-mouse CD62L MEL-14 25 ug BioLegend 104430 PerCP anti-mouse CD62L MEL-14 100 ug BioLegend 104431 PerCP/Cyanine5.5 anti-mouse CD62L MEL-14 25 ug BioLegend 104437 Brilliant Violet 605™ anti-mouse CD62L MEL-14 125 uL BioLegend 104438 Brilliant Violet 605™ anti-mouse CD62L MEL-14 50 ug BioLegend 104440 Brilliant Violet 785™ anti-mouse CD62L MEL-14 50 ug BioLegend 104445 Brilliant Violet 711™ anti-mouse CD62L MEL-14 50 ug BioLegend 104447 PE/Dazzle™ 594 anti-mouse CD62L MEL-14 25 ug