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- 库存：
99
- 英文名：
APC anti-mouse CD150 (SLAM)
- 供应商：
北京云肽生物科技有限公司
BioLegend 115909 APC anti-mouse CD150 (SLAM)
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
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BioLegend 115909 APC anti-mouse CD150 (SLAM)
产品简介：
产品品牌：BioLegend
产品货号：115909
产品名称：BioLegend 115909 APC anti-mouse CD150 (SLAM)
产品规格：25 µg
产品说明：
Clone TC15-12F12.2 (See other available formats)
Regulatory Status RUO
Other Names Signaling Lymphocyte Activation Molecule (SLAM), IPO-3
Isotype Rat IgG2a, λ
描述
CD150是免疫球蛋白超家族的75-95kD成员，也称为SLAM（信号淋巴细胞活化分子）或IPO-3。CD150是一种单链I型跨膜分子，在胸腺细胞、T细胞亚群、B细胞、树突状细胞和内皮细胞上表达。该表达在激活时上调。CD150表达已显示在Th1克隆上维持，但在Th2克隆上不维持。T调节细胞表达相对高水平的CD150。抗CD150的抗体已被证明能增加Th1细胞产生IFN-γ，尤其是当通过TCR共同刺激时。CD150与src同源性2-结构域酪氨酸磷酸酶SHP-2结合，这种结合被认为与信号转导有关。CD150与CD48结合是造血干细胞研究的有用标志物。
CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoietic stem cell studies.
Product Details
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen Mouse SLAM-human IgG1 fusion protein
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration 0.2 mg/ml
Storage & Handling The CD150 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser Red Laser (633 nm)
Application Notes
The TC15-12F12.2 antibody has been reported to enhance the production of IFN-? by Th1 cells stimulated through TCR. Additional reported applications (for the relevant formats) include: immunoprecipitaion17, enhancing IFN-? production by Th1 cells when stimulated with CD31, and inhibiting CD3 induced T cell proliferation6. The Ultra-LEAF™ purified antibody (Endotoxin <0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 115949 & 115950).
Antigen Details
Structure Ig superfamily, 75-95 kD
Distribution Thymocytes, T cell subset, B lymphocytes, dendritic cells, endothelial cells
Function B cell and dendritic cell costimulation
Ligand/Receptor CD150
Cell Type B cells, Dendritic cells, Endothelial cells, T cells, Thymocytes, Tregs
Biology Area Costimulatory Molecules, Immunology, Innate Immunity
Molecular Family Adhesion Molecules, CD Molecules
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BioLegend 115909 APC anti-mouse CD150 (SLAM)
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