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- 2025年12月05日
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JAK kinase-IN-1
CAS No. : 2698389-43-2
MCE 国际站：JAK kinase-IN-1
产品活性：JAK kinase-IN-1 (Example 1) 是一种 JAK 抑制剂。JAK kinase-IN-1 抑制 TYK2, JAK1, JAK2 和 JAK3 的 IC50 分别为 4.2 nM, 32 nM, 27 nM, 3473 nM。
研究领域：Epigenetics | Protein Tyrosine Kinase/RTK | JAK/STAT Signaling | Stem Cell/Wnt
作用靶点：JAK
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文献和实验Recently, a point mutation in the JAK2 gene, JAK2 V617F , was discovered in several myeloid proliferative neoplasms including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Demonstration
Production and Crystallization of Recombinant JAK Proteins
JAK kinases are critical mediators in development, differentiation, and homeostasis and accordingly, have become well-validated targets for drug discovery efforts. In recent years, the integration of X-ray crystallography in kinase-focused
In Vitro JAK Kinase Activity and Inhibition Assays
The discovery that a range of myeloproliferative diseases and leukemias are associated with Janus Kinase (JAK) mutations has highlighted the importance of JAK/STAT signalling in disease and sparked a renewed interest in developing JAK
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