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- Biorbyt
- 英国
- orb2277665
- 2026年08月07日
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- 文献和实验
- 技术资料
- 保存条件：
详询
- 保质期：
12 months from date of receipt.
- 英文名：
JAK kinase-IN-1
- 库存：
99
- 供应商：
Biorbyt
- CAS号：
2698389-43-2
- 规格：
50 mg/5 mg
| 规格： | 50 mg | 产品价格： | ￥0.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥0.0 |
描述: JAK kinase-IN-1 is a potent small-molecule inhibitor of the JAK family, demonstrating high potency against TYK2, JAK1, and JAK2. It serves as a valuable research tool for investigating JAK/STAT signaling pathways in both cellular and biochemical assays for immunology and oncology research.
靶点: JAK
分子式: C17H19F2N7OS
分子量: 407.44
SMILES: C(=O)(N1C2(CN(CC1(SC2)[H])C3=NC(NC=4C=NN(C)C4)=NC=C3)[H])[C@H]5C(F)(F)C5
研究领域: Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
保存条件: -20°C
备注: For research use only.
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文献和实验Recently, a point mutation in the JAK2 gene, JAK2 V617F , was discovered in several myeloid proliferative neoplasms including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Demonstration
Production and Crystallization of Recombinant JAK Proteins
JAK kinases are critical mediators in development, differentiation, and homeostasis and accordingly, have become well-validated targets for drug discovery efforts. In recent years, the integration of X-ray crystallography in kinase-focused
In Vitro JAK Kinase Activity and Inhibition Assays
The discovery that a range of myeloproliferative diseases and leukemias are associated with Janus Kinase (JAK) mutations has highlighted the importance of JAK/STAT signalling in disease and sparked a renewed interest in developing JAK
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