- 询价
- Cell Signaling Technology
- 3707
- USA
- 2025年08月08日
- W, IP
- Rabbit
- H,M
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 抗体英文名：
TNF-α Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding Gly198 of human TNF-α protein
- 应用范围：
W, IP
- 宿主：
Rabbit
- 保质期：
详见说明书
- 库存：
大量
- 供应商：
CST
- 适应物种：
H,M
- 级别：
详见MSDS文件
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP | H M | Endogenous | 17 mature. 25 precursor. | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | TNF-α Antibody detects endogenous levels of mature TNF-α as well TNF-α precursor protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly198 of human TNF-α protein. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from Raw 264.7 cells, untreated (-) or LPS-treated (1 µg/ml, 18 hr; +), using TNF-α Antibody. Western Blotting
Western blot analysis of recombinant Human Tumor Necrosis Factor-α (hTNF-α) #8902 using TNF-α Antibody. |
| Background | TNF-α, the prototypical member of the TNF protein superfamily, is a homotrimeric type-II membrane protein (1,2). Membrane-bound TNF-α is cleaved by the metalloprotease TACE/ADAM17 to generate a soluble homotrimer (2). Both membrane and soluble forms of TNF-α are biologically active. TNF-α is produced by a variety of immune cells including T cells, B cells, NK cells, and macrophages (1). Cellular response to TNF-α is mediated through interaction with receptors TNF-R1 and TNF-R2 and results in activation of pathways that favor both cell survival and apoptosis depending on the cell type and biological context. Activation of kinase pathways (including JNK, Erk (p44/42), p38 MAPK, and NF-κB) promotes the survival of cells, while TNF-α-mediated activation of caspase-8 leads to programmed cell death (1,2). TNF-α plays a key regulatory role in inflammation and host defense against bacterial infection, notably Mycobacterium tuberculosis (3). The role of TNF-α in autoimmunity is underscored by blocking TNF-α action to treat rheumatoid arthritis and Crohn’s disease (1,2,4). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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- 作者
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文献和实验Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
ph1996 请教各位战友： 刚买来细胞因子TNF-α，peprotech公司的产品，说明书中未具体说明这个细胞因子是如何来配，以及长期保存的话如何配母液。请各位用过这个细胞因子的战友给解答一下，谢谢，在线等~~~~ ph1996 说明书中提到，如果长期保存，可以用含有0.1%的BSA的BUFFER来存，可这个BUFFER是什么啊？ freecell 按照蛋白质的保存
兔肿瘤坏死因子α（TNF-α） 酶联免疫 分析（ ELISA ） 试剂 盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定兔血清，血浆及相关液体样本中 肿瘤坏死因子 α （TNF- α ） 的 含量。 实验原理 ： 本试剂盒应用双抗体夹心法测定 标本 中 兔肿瘤坏死因子 α （ TNF- α ） 水平。用纯化的 兔肿瘤坏死因子 α （ TNF- α ） 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 肿瘤
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