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RSK1/RSK2/RSK3 Antibody

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  • 询价
  • Cell Signaling Technology已认证
  • USA
  • 2025年08月22日
  • W
  • Rabbit
  • H,M,R,Mk,C
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    • 详细信息
    • 技术资料
    • 抗体英文名

      RSK1/RSK2/RSK3 Antibody

    • 抗原

      synthetic peptide corresponding to residues surrounding Asp659 of human p90RSK

    • 应用范围

      W

    • 宿主

      Rabbit

    • 级别

      详见MSDS文件

    • 供应商

      CST

    • 保质期

      详见说明书

    • 库存

      大量

    • 适应物种

      H,M,R,Mk,C

    • 是否单克隆

      2

    • 保存条件

      -20°c

    • 规格

      100 ul (10 western blots)/carrier free & custom formulation / quantity

    规格:产品价格:¥请询价
    规格:100 ul (10 western blots)产品价格:¥请询价
    规格:carrier free & custom formulation / quantity产品价格:¥请询价

    pathway more info application references datasheet PDF MSDS PDF protocols

    Applications Key:  W=Western Blotting
    Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Monkey  C=Chicken
    Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

    Applications Reactivity Sensitivity MW (kDa) Source
    W H M R Mk (C) Endogenous 90 Rabbit
    Protocols
    Specificity / Sensitivity

    RSK1/RSK2/RSK3 Antibody detects endogenous levels of RSK1, RSK2 and RSK3 proteins.

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp659 of human p90RSK. Antibodies are purified by protein A and peptide affinity chromatography.

    Western Blotting

    Western Blotting

    Western blot analysis of extracts from L929, JB6, HeLa, PC12 and COS cells, using RSK1/RSK2/RSK3 Antibody.

    Background

    The 90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed serine/threonine kinases characterized by two nonidentical, functional kinase domains (1) and a carboxy-terminal docking site for extracellular signal-regulated kinases (ERKs) (2). Several sites both within and outside of the RSK kinase domain, including Ser380, Thr359, Ser363, and Thr573, are important for kinase activation (3). RSK1-3 are activated via coordinated phosphorylation by MAPKs, by autophosphorylation, and by phosphoinositide-3-OH kinase (PI3K) in response to many growth factors, polypeptide hormones, and neurotransmitters (3).

    1. Fisher, T.L. and Blenis, J. (1996) Mol Cell Biol 16, 1212-9.
    2. Smith, J.A. et al. (1999) J Biol Chem 274, 2893-8.
    3. Dalby, K.N. et al. (1998) J Biol Chem 273, 1496-505.
    Application References

    Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !

    Companion Products

    For Research Use Only. Not For Use In Diagnostic Procedures.

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