- 询价
- Cell Signaling Technology
- 3732
- USA
- 2025年09月01日
- W
- Rabbit
- H,M,Mk
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
GP130 Antibody
- 抗原：
synthetic peptide corresponding to the sequence of human GP130
- 应用范围：
W
- 宿主：
Rabbit
- 保质期：
详见说明书
- 适应物种：
H,M,Mk
- 库存：
大量
- 级别：
详见MSDS文件
- 供应商：
CST
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M Mk | Endogenous | 130 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | GP130 Antibody detects endogenous levels of total GP130 protein independent of phosphorylation. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human GP130. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from NIH/3T3, PC12, COS and HeLa cells, using GP130 Antibody. |
| Background | GP130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines (1-3). The binding of a ligand to its receptor induces the dimerization of GP130, leading to activation of the Jak tyrosine kinase and to tyrosine phosphorylation of GP130. These events lead to the activation of multiple signal-transduction pathways, such as the Stat, Ras-MAPK and PI3 kinase pathways, whose activation is controlled by distinct regions of GP130 (4-7).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验The HIV-1 entry receptors are CD4 and a chemokine receptor (CCR5 or CXCR4). In addition it has recently been demonstrated that HIV-1 gp120 binds to and signals through integrin α4 β7 , the gut-homing receptor (Arthos et al., Nat Immunol
埃博拉病毒（EBOV）复制周期中的关键步骤会涉及到病毒糖蛋白 2（GP2）的构象改变，从而促进宿主 - 病毒膜融合，释放病毒基因组的过程。这个蛋白的作用和 HIV 的 GP41 的作用机制类似。这篇文章针对 EBOV 的 GP2 蛋白为靶点进行虚拟筛选，所选用的分子库包含大约 170 万个分子，使用传统的 DOCK 软件进行对接，从排名前列的化合物中，选出 165 种购买并进行生物活性检测，发现了 4 个良好的候选化合物，其 IC50 在 3 - 26uM 之间。在随后的分子动力学模拟中，发现
Inhibition of HIV Infection by Lectin Binding to gp120
Human immunodeficiency virus (HIV) is the causative agent of AIDS (acquired immunodeficiency syndrome). The polypeptide precursor gp160 of HIV-1 forms the external glycoprotein, gp120 and the transmembrane glycoprotein, gp41 (1 ). Sequence
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