- 询价
- Cell Signaling Technology
- 9039
- USA
- 2025年07月15日
- W, IP, IF-F
- H,M,R,Mk
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- 详细信息
- 技术资料
- 抗体英文名：
NDRG4 (D4A6) Rabbit mAb
- 抗原：
synthetic peptide corresponding to residues surrounding Gly217 of human NDRG4 protein
- 应用范围：
W, IP, IF-F
- 供应商：
CST
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 适应物种：
H,M,R,Mk
- 库存：
大量
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IF-F=Immunofluorescence (Frozen)
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP IF-F | H M R (Mk) | Endogenous | 37-45 | Rabbit IgG |
| Protocols | |
|---|---|
| Specificity / Sensitivity | NDRG4 (D4A6) Rabbit mAb recognizes endogenous levels of total NDRG4 protein. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly217 of human NDRG4 protein. Western Blotting
Western blot analysis of extracts from human cerebellum, mouse brain, and rat brain using NDRG4 (D4A6) Rabbit mAb. Western Blotting
Western blot analysis of extracts from various cell lines using NDRG4 (D4A6) Rabbit mAb. Western Blotting
Western blot analysis of 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human NDRG4 (hNDRG4-Myc/DDK, +), using NDRG4 (D4A6) Rabbit mAb. IF-F
Confocal immunofluorescent analysis of adult mouse brain using NDRG4 (D4A6) Rabbit mAb and Neurofilament-L (C28E10) Rabbit mAb (Alexa Fluor® 555 Conjugate) #8039 (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). |
| Background | The NDRG (N-Myc downstream-regulated gene) family, consisting of NDRG1, NDRG2, NDRG3, and NDRG4, are a group of structurally related proteins with roles in cell proliferation, differentiation, apoptosis, stress responses, and cell migration/metastasis (1-3). NDRG1 was originally identified as a protein that was up-regulated in N-Myc knockout mice (1). Proteins in the NDRG family, particularly NDRG1 and NDRG2, have been reported to be down-regulated in various cancer tissues, and have been suggested to function as a tumor suppressors (4,5). Unlike other members of the family that are widely expressed, NDRG4/Bdm1 expression is restricted primarily to the heart and brain (2,3,6,7). Multiple alternatively spliced isoforms of NDRG4 have been reported (3,7). Expression of NDRG4 is reduced in the brain of patients with Alzheimer's disease (3). In contrast, NDRG4 expression is elevated in glioblastoma and contributes to cell cycle progression and survival (8). NDRG4 also may be inactivated by promotor methylation in colorectal cancer and function as a tumor suppressor gene (9).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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