Chebulic Acid

一种具有多种生物活性的苯酚；在100µg/ml浓度下可减少HUVEC中甘油-AGE诱导的ROS生成；减少HUVEC对THP-1单核细胞的甘油-AGE诱导粘附；诱导Nrf2核转位和GSH合成并抑制LX-2肝星状细胞中甘油-AGE诱导的胶原积累；在25和50mg/kg剂量下可增加缺血-再灌注诱发性肾病糖尿病大鼠模型中的血清胰岛素水平并降低血尿素氮水平、蛋白尿、白蛋白尿和血清葡萄糖水平A phenol with diverse biological activities; reduces glycer-AGE-induced production of ROS in HUVECs at 100 µg/ml; reduces glycer-AGE-induced adhesion of HUVECs to THP-1 monocytes; induces Nrf2 nuclear translocation and GSH synthesis and inhibits glycer-AGE-induced collagen accumulation in LX-2 hepatic stellate cells; increases serum insulin levels and reduces blood urea nitrogen levels, proteinuria, albuminuria, and serum glucose levels in a diabetic rat model of ischemia-reperfusion-induced nephropathy at 25 and 50 mg/kg.