- 询价
- Cell Signaling Technology
- 4754
- USA
- 2026年05月28日
- W, IP
- H,M,R
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- 文献和实验
- 技术资料
- 抗体英文名：
HER3/ErbB3 (1B2E) Rabbit mAb
- 抗原：
synthetic peptide corresponding to residues surrounding Tyr867 of human ErbB3
- 应用范围：
W, IP
- 适应物种：
H,M,R
- 级别：
详见MSDS文件
- 供应商：
CST
- 库存：
大量
- 保质期：
详见说明书
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP | H (M) (R) | Endogenous | 185 | Rabbit IgG |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | HER3/ErbB3 (1B2) Rabbit mAb detects endogenous levels of total HER3/ErbB3 proteins. This antibody does not cross-react with other ErbB family members. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr867 of human ErbB3. Western Blotting
Western blot analysis of MCF7 and T47D cell lysates, using HER3/ErbB3 (1B2) Rabbit mAb. |
| Background | HER3/ErbB3 is a member of the ErbB receptor protein tyrosine kinase family, but it lacks tyrosine kinase activity. Tyrosine phosphorylation of ErbB3 depends on its association with other ErbB tyrosine kinases. Upon ligand binding, heterodimers form between ErbB3 and other ErbB proteins, and ErbB3 is phosphorylated on tyrosine residues by the activated ErbB kinase (1,2). There are at least 9 potential tyrosine phosphorylation sites in the carboxy-terminal tail of ErbB3. These sites serve as consensus binding sites for signal transducing proteins, including Src family members, Grb2, and the p85 subunit of PI3 kinase, which mediate ErbB downstream signaling (3). Both Tyr1222 and Tyr1289 of ErbB3 reside within a YXXM motif and participate in signaling to PI3K (4).Investigators have found that ErbB3 is highly expressed in many cancer cells (5) and activation of the ErbB3/PI3K pathway is correlated with malignant phenotypes of adenocarcinomas (6). Research studies have demonstrated that in tumor development, ErbB3 may function as an oncogenic unit together with other ErbB members (e.g. ErbB2 requires ErbB3 to drive breast tumor cell proliferation) (7). Thus, investigators view inhibiting interaction between ErbB3 and ErbB tyrosine kinases as a novel strategy for anti-tumor therapy.
|
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
Rabbit Monoclonals Produced Using Epitomics® Technology, U.S. Patent No. 5,675,063. For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验ERBB3/HER3最-新靶点进展：从“不可成药”到ADC与双抗ADC的分层格局
ERBB3/HER3因其激酶结构域缺陷，长期被视为难以成药的“伪靶点”，其致癌功能高度依赖与HER2/EGFR的异二聚化。2026年的临床证据表明，靶向策略的重心已从信号阻断型单抗，彻底转向不依赖激酶活性、通过内吞递送细胞毒载荷的ADC，以及同时阻断二聚化与递送载荷的双特异性ADC。SHR-A2009的首--个III期研究达到主要终点并获上市申请受理，标志着HER3 ADC向监管批准迈出了实质性一步。与此同时，iza-bren（BL-B01D1）作为EGFR×HER3双抗ADC，在乳腺
Generation of Rabbit Immune Libraries
Rabbits provide an interesting alternative to antibodies derived from the murine system. Furthermore, rabbits show an exceptional feature with respect to the mechanisms that are used for the generation of antibody diversity, i.e. a single VH
T-Cell Activation Using mAb to CD3
µg/ml solution of anti-CD3e (145-2C11) in sterile PBS. Calculate the number of wells required for each experimental condition and consider triplicate samples for each condition. For example, to coat one-half plate (48 wells) 2.6ml of antibody solution
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