- 询价
- Cell Signaling Technology
- 3224
- USA
- 2026年10月11日
- W, IP
- H,M,R,Mk
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- 文献和实验
- 技术资料
- 抗体英文名：
Dvl2 (30D2) Rabbit mAb
- 抗原：
synthetic peptide corresponding to residues surrounding Gly176 of human Dvl2
- 应用范围：
W, IP
- 供应商：
CST
- 级别：
详见MSDS文件
- 适应物种：
H,M,R,Mk
- 保质期：
详见说明书
- 库存：
大量
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
40 ul (4 western blots)/100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 40 ul (4 western blots) | 产品价格： | ￥请询价 |
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP | H M R Mk | Endogenous | 90 to 95 | Rabbit IgG |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Dvl2 (30D2) Rabbit mAb detects endogenous levels of total Dvl2 protein. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly176 of human Dvl2. Western Blotting
Western blot analysis of total cell lysates from various cell lines using Dvl2 (30D2) Rabbit mAb. Western Blotting
Western blot analysis of total cell lysates from Rat2 and NIH/3T3 cells, untreated or treated with conditioned medium containing Wnt3a for 60 minutes and also treated with or without calf intestinal phosphatase (CIP), using Dvl2 (30D2) Rabbit mAb. |
| Background | Dishevelled (Dsh) proteins are important intermediates of Wnt signaling pathways. Dsh inhibits glycogen synthase kinase-3β promoting β-catenin stabilization. Dsh proteins also participate in the planar cell polarity pathway by acting through JNK (1,2). There are three Dsh homologs, Dvl1, Dvl2 and Dvl3 in mammals. Upon treatment with Wnt proteins, Dvls become hyperphosphorylated (3) and accumulate in the nucleus (4). Dvl proteins also associate with actin fibers and cytoplasmic vesicular membranes (5) and mediate endocytosis of the Fzd receptor after Wnt protein stimulation (6). Overexpression of Dvl has been reported in certain cancers (7,8).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
Rabbit Monoclonals Produced Using Epitomics® Technology, U.S. Patent No. 5,675,063. For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验T-Cell Activation Using mAb to CD3
spectrophotometer Experiment Duration 30 minutes preparation of PBMC 20 minutes to set up the assay 2-4 days incubation Method Prepare PBMC and resuspend the cells at 1-2x106 /ml of complete RPMI. Note: This density of PBMC
：使用 Anti-phospho-Akt (Ser473) Rabbit mAb 对石蜡包埋的人乳腺癌组织进行免疫组织化学分析。（图 A）使用免疫组化试剂盒M&R HRP/DAB Detection IHC Kit，抗体 1:100 稀释；(图 B) 采用普通免疫组化试剂盒，抗体 1:25 稀释。 图 6 免疫组化实验检测 Erk1/2 表达 注：使用 Anti-Erk1/2 Mouse mAb与p44/42 MAPK （Erk1/2）Rabbit mAb 对正常小鼠心脏组织进行免疫
。这种"代谢-免疫-表观"的三维调控，使丙酮酰化成为连接Warburg效应与细胞命运的核心节点。 相关产品推荐 货号 名称 产品类别 S0B60315 S-RMabMix™ Pyruvoyl Lysine Rabbit mAb 丙酮酰化抗体 S0B0655 S-RMabMix™ Acetyllysine Rabbit mAb 乙酰化抗体 S0F0017 Premium Anti-acetyllysine agarose Beads 乙酰化琼脂糖珠 S0B0719 S
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