PCR array ——细胞信号通路与基因功能研究利器

PCR array亦被称为功能分类芯片或PCR列阵，它结合了实时定量PCR技术灵敏可靠的优势以及微阵列技术同时检测多种基因表达量的优势，是分析信号通路或某生物学功能相关基因表达状态的首选工具。PCR array使用荧光定量PCR的方法，原理简单，全部引物经过实验验证，结果可靠，兼容性好。在一张96孔或384孔板上可同时对某个信号通路或某生物学功能相关的84个或372个重要基因的表达量变化进行检测（其余为对照样本孔）。采用PCR array可一次性对某种疾病、信号通路或生物学过程相关的多个基因的表达进行定量分析。

其应用领域十分广泛，主要有肿瘤、免疫、发育、代谢、干细胞、细胞生物学、细胞信号通路、心血管疾病、miRNA靶基因等。可用于检测的物种主要是人类(Homo sapiens)，小鼠(Mus musculus)，大鼠(Rattus norvegicus)和恒河猴(Rhesus macaque)，其他物种可进行订制。

RT2Profiler PCR Array Pathways : 96-/100-well & 384HT
PAHS/MM/RN (189 Total Pathways)
Adherens Junctions	146Z	Liver Cancer	133Z
Adipogenesis	049Z	Lung Cancer	134Z
Aging	178Z	Lymphoma	139Z
Allergy & Asthma	067Z	Macular Degeneration	171Z
Alzheimer's Disease	057Z	Male Infertility	165Z
Amino Acid Metabolism I	129Z	MAP Kinase Signaling Pathway	061Z
Amino Acid Metabolism II	130Z	Mesenchymal Stem Cells	082Z
AMPK Signaling	175Z	miR-1 & miR-206 Targets	6005Z
Androgen Receptor Signaling Targets	142Z	miR-9 Targets	6014Z
Angiogenesis	024Z	miR-17 & miR-20a Targets	6003Z
Angiogenic Growth Factors	072Z	miR-21 Targets	6001Z
Antibacterial Response	148Z	miR-29 Targets	6012Z
Antifungal Response	147Z	miR-34a1 Targets	6006Z
Antiviral Response	122Z	miR-146a Targets	6004Z
Apoptosis	012Z	miR-153 Targets	6013Z
Apoptosis 384HT	3012Z	miR-155 Targets	6002Z
Atherosclerosis	038Z	miR-181 Targets	6011Z
Autophagy	084Z	miR-210 Targets	6009Z
Breast Cancer	131Z	miR-221 & miR-222 Targets	6007Z
Estrogen Receptor Signaling	005Z	miR-4514 & miR-4692 Targets	6010Z
cAMP / Calcium Signaling PathwayFinder	066Z	let-7 Targets	6008Z
Cancer Drug Resistance	004Z	Mitochondria	087Z
Cancer Drug Targets	507Z	Mitochondrial Energy Metabolism Plus	008Y
Cancer PathwayFinder™	033Z	mTOR Signaling	098Z
Cancer Stem Cells	176Z	Molecular Toxicology PathwayFinder	401Z
Cardiotoxicity	095Z	Molecular Toxicology PathwayFinder 384HT	3401Z
Cardiovascular Disease	174Z	Multiple Sclerosis	125Z
Cell Cycle	020Z	MYC Targets	177Z
Cell Death PathwayFinderTM	212Z	Necrosis	141Z
Cell Junction PathwayFinderTM	213Z	Nephrotoxicity	094Z
Cell Lineage Identification	508Z	Neurogenesis	404Z
Cell Motility	128Z	Neuronal Ion Channels	036Z
Cell Surface Markers	055Z	Neurotoxicity	096Z
Cellular Senescence	050Z	Neurotransmitter Receptors	060Z
Cellular Stress Responses	019Z	Neurotrophins & Receptors	031Z
Chemokines & Receptors	022Z	NFkB Signaling Pathway Plus	025Y
Circadian Rhythms	153Z	NFkB Signaling Targets	225Z
Common Cytokines	021Z	Nitric Oxide Signaling Pathway	062Z
Crohn's Disease	169Z	Notch Signaling Pathway Plus	059Y
Cystic Fibrosis	167Z	Notch Signaling Targets	259Z
Cytokines & Chemokines	150Z	Nuclear Receptors & Coregulators	056Y
Cytoskeleton Regulators	088Z	Obesity	017Z
Dendritic & Antigen Presenting Cell	406Z	Oncogenes & Tumor Suppressor Genes	502Z
Diabetes	023Z	Osmotic Stress	151Z
DNA Damage Signaling Pathway	029Z	Osteogenesis	026Z
DNA Repair	042Z	Osteporosis	170Z
Dopamine and Serotonin Pathway	158Z	Oxidative Stress Plus	065Y
Drug Metabolism	002Z	p53 Signaling Pathway	027Z
Drug Metabolism: Phase I Enzymes	068Z	Pain: Neuropathic & Inflammatory	162Z
Drug Metabolism: Phase II Enzymes	069Z	Parkinson's Disease	124Z
Drug Transporters	070Z	Phagocytosis	173Z
EGF / PDGF Signaling Pathway	040Z	PI3K-AKT Signaling Pathway	058Z
Embryonic Stem Cells (Version Y)	081Y	Polycomb & Trithorax Target Genes	505Z
Endothelial Cell Biology	015Z	Polycomb & Trithorax Complexes	506Z
Epigenetic Chromatin Modification Enzymes	085Z	Polycystic Kidney Disease	168Z
Epigenetic Chromatin Remodeling Factors	086Z	PPAR Targets	149Z
Epithelial to Mesenchymal Transition	090Z	Pre-Eclampsia	163Z
Extracellular Matrix & Adhesion Molecules	013Z	Primary Cilia	127Z
Fatty Acid Metabolism	007Z	Prostate Cancer	135Z
Fatty Liver	157Z	Protease Activated Receptor Signaling	159Z
Female Infertility	164Z	Protein Phosphatases	045Z
Fibrosis	120Z	Signal Transduction PathwayFinder™	014Z
Focal Adhesions	145Z	Skeletal Muscle: Myogenesis & Myopathy	099Z
GABA & Glutamate	152Z	Stem Cell	405Z
Gap Junctions	144Z	Stem Cell Signaling	047Z
Glucocorticoid Signaling	154Z	Stem Cell Transcription Factors	501Z
Glucose Metabolism	006Z	Stress & Toxicity PathwayFinder	003Z
Glycosylation	046Z	Synaptic Plasticity	126Z
G Protein Coupled Receptors 384HT	3009Z	T Cell Anergy & Immune Tolerance	074Z
GPCR Signaling PathwayFinder	071Z	T Helper Cell Differentiation	503Z
Growth Factors	041Z	T-Cell & B-Cell Activation	053Z
Heat Shock Proteins & Chaperones	076Z	Telomeres & Telomerase	010Z
Hedgehog Signaling Pathway	078Z	Terminal Differentiation Markers	048Z
Hematopoiesis	054Z	TGFb / BMP Signaling Pathway Plus	035Y
Hepatotoxicity	093Z	TGFb Signaling Targets	235Y
Hippo Signaling Pathway	172Z	Th17 Response	073Z
HIV Host Response (Human ONLY)	051Y	Th1 & Th2	034Z
Homeobox (HOX) Genes	083Z	Tight Junctions	143Z
Housekeeping Genes	000Z	TNF Signaling Pathway	063Z
Huntington's Disease	123Z	Toll-Like Receptor Signaling Pathway	018Z
Hypertension	037Z	Transcription Factors	075Z
Hypoxia Signaling Pathway Plus	032Y	Transplant Rejection	166Z
Induced Pluripotent Stem Cells	092Z	Tumor Metastasis	028Z
IL6/STAT3 Signaling Pathway Plus	160Y	Type I Interferon Response	016Z
Immunotoxicity	179Z	Tyrosine Kinases	161Z
Inflammasomes	097Z	Ubiquitination (Ubiquitinylation)	079Z
Inflammatory Cytokines & Receptors	011Z	Ubiquitin Ligases 384HT	3079Z
Inflammatory Response & Autoimmunity	077Z	Unfolded Protein Response Plus	089Y
Inflammatory Response & Autoimmunity 384HT	3803Z	VEGF Signaling	091Z
Innate & Adaptive Immune Responses	052Z	WNT Signaling Pathway Plus	043Y
Insulin Resistance	156Z	WNT Signaling Targets	243Z
Insulin Signaling Pathway	030Z	Wound Healing	121Z
Interferons & Receptors	064Z	RT2RNA QC	999Z
JAK / STAT Signaling Pathway	039Y	Calibration Plate - Predispensed with Primer - Human	996
Leukemia	137Z	Calibration Plate - Predispensed with PCR Cocktail Mixture - Human	997
Let-7a Targets	6008Y	Calibration Plate - With PCR Cocktail Mixture in Tube - Human	998
Lipoprotein Signaling & Cholesterol Metabolism	080Z
PCR Arrays in Plus version Only available for Human samples; other species received 'non-Plus' version

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Common Cytokines	021Z	Nitric Oxide Signaling Pathway	062Z
Crohn's Disease	169Z	Notch Signaling Pathway Plus	059Y
Cystic Fibrosis	167Z	Notch Signaling Targets	259Z
Cytokines & Chemokines	150Z	Nuclear Receptors & Coregulators	056Y
Cytoskeleton Regulators	088Z	Obesity	017Z
Dendritic & Antigen Presenting Cell	406Z	Oncogenes & Tumor Suppressor Genes	502Z
Diabetes	023Z	Osmotic Stress	151Z
DNA Damage Signaling Pathway	029Z	Osteogenesis	026Z
DNA Repair	042Z	Osteporosis	170Z
Dopamine and Serotonin Pathway	158Z	Oxidative Stress Plus	065Y
Drug Metabolism	002Z	p53 Signaling Pathway	027Z
Drug Metabolism: Phase I Enzymes	068Z	Pain: Neuropathic & Inflammatory	162Z
Drug Metabolism: Phase II Enzymes	069Z	Parkinson's Disease	124Z
Drug Transporters	070Z	Phagocytosis	173Z
EGF / PDGF Signaling Pathway	040Z	PI3K-AKT Signaling Pathway	058Z
Embryonic Stem Cells (Version Y)	081Y	Polycomb & Trithorax Target Genes	505Z
Endothelial Cell Biology	015Z	Polycomb & Trithorax Complexes	506Z
Epigenetic Chromatin Modification Enzymes	085Z	Polycystic Kidney Disease	168Z
Epigenetic Chromatin Remodeling Factors	086Z	PPAR Targets	149Z
Epithelial to Mesenchymal Transition	090Z	Pre-Eclampsia	163Z
Extracellular Matrix & Adhesion Molecules	013Z	Primary Cilia	127Z
Fatty Acid Metabolism	007Z	Prostate Cancer	135Z
Fatty Liver	157Z	Protease Activated Receptor Signaling	159Z
Female Infertility	164Z	Protein Phosphatases	045Z
Fibrosis	120Z	Signal Transduction PathwayFinder™	014Z
Focal Adhesions	145Z	Skeletal Muscle: Myogenesis & Myopathy	099Z
GABA & Glutamate	152Z	Stem Cell	405Z
Gap Junctions	144Z	Stem Cell Signaling	047Z
Glucocorticoid Signaling	154Z	Stem Cell Transcription Factors	501Z
Glucose Metabolism	006Z	Stress & Toxicity PathwayFinder	003Z
Glycosylation	046Z	Synaptic Plasticity	126Z
G Protein Coupled Receptors 384HT	3009Z	T Cell Anergy & Immune Tolerance	074Z
GPCR Signaling PathwayFinder	071Z	T Helper Cell Differentiation	503Z
Growth Factors	041Z	T-Cell & B-Cell Activation	053Z
Heat Shock Proteins & Chaperones	076Z	Telomeres & Telomerase	010Z
Hedgehog Signaling Pathway	078Z	Terminal Differentiation Markers	048Z
Hematopoiesis	054Z	TGFb / BMP Signaling Pathway Plus	035Y
Hepatotoxicity	093Z	TGFb Signaling Targets	235Y
Hippo Signaling Pathway	172Z	Th17 Response	073Z
HIV Host Response (Human ONLY)	051Y	Th1 & Th2	034Z
Homeobox (HOX) Genes	083Z	Tight Junctions	143Z
Housekeeping Genes	000Z	TNF Signaling Pathway	063Z
Huntington's Disease	123Z	Toll-Like Receptor Signaling Pathway	018Z
Hypertension	037Z	Transcription Factors	075Z
Hypoxia Signaling Pathway Plus	032Y	Transplant Rejection	166Z
Induced Pluripotent Stem Cells	092Z	Tumor Metastasis	028Z
IL6/STAT3 Signaling Pathway Plus	160Y	Type I Interferon Response	016Z
Immunotoxicity	179Z	Tyrosine Kinases	161Z
Inflammasomes	097Z	Ubiquitination (Ubiquitinylation)	079Z
Inflammatory Cytokines & Receptors	011Z	Ubiquitin Ligases 384HT	3079Z
Inflammatory Response & Autoimmunity	077Z	Unfolded Protein Response Plus	089Y
Inflammatory Response & Autoimmunity 384HT	3803Z	VEGF Signaling	091Z
Innate & Adaptive Immune Responses	052Z	WNT Signaling Pathway Plus	043Y
Insulin Resistance	156Z	WNT Signaling Targets	243Z
Insulin Signaling Pathway	030Z	Wound Healing	121Z
Interferons & Receptors	064Z	RT2RNA QC	999Z
JAK / STAT Signaling Pathway	039Y	Calibration Plate - Predispensed with Primer - Human	996
Leukemia	137Z	Calibration Plate - Predispensed with PCR Cocktail Mixture - Human	997
Let-7a Targets	6008Y	Calibration Plate - With PCR Cocktail Mixture in Tube - Human	998
Lipoprotein Signaling & Cholesterol Metabolism	080Z
PCR Arrays in Plus version Only available for Human samples; other species received 'non-Plus' version