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抗人eif4e多克隆抗体
- 参考价格： ¥3300.0
- 品 牌： abgent
- 货 号： AE1011c
- 适应物种： 人
- 应用范围： 免疫印迹,免疫组化,免疫荧光
- 克 隆 性： 多克隆
- 亚 型： Rabbit IgG
- 抗体类型： 一抗
产品概览
| 背景： | The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.REFERENCESOver-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma. Tu L, et al. Mol Cancer, 2010 Apr 16. PMID 20398343.Nuclear assortment of eIF4E coincides with shut-off of host protein synthesis upon poliovirus infection. Sukarieh R, et al. J Gen Virol, 2010 May. PMID 20053821.NAD(P)H quinone-oxydoreductase 1 protects eukaryotic translation initiation factor 4GI from degradation by the proteasome. Alard A, et al. Mol Cell Biol, 2010 Feb. PMID 20028737.HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage. Castell贸 A, et al. PLoS One, 2009 Nov 24. PMID 19956697.The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G. Suzuki Y, et al. J Biol Chem, 2009 Dec 18. PMID 19850929. |
| 其他名字： | p220; Eukaryotic translation initiation factor 4 gamma 1, eIF-4-gamma 1; eIF-4G 1; eIF-4G1 |
| 浓度： | 1mg/ml |
靶点信息
| 基因id： | 1981 |
| 蛋白名： | EIF4G1 |
| 同义词： | EIF4F, EIF4G, EIF4GI |
应用与保存
| 稀释浓度： | WB~~1:500~1:1000IHC~~1:50~1:100IF~~1:100~200 |
| 注意事项： | EIF4E Antibody (S1232) is for research use only and not for use in diagnostic or therapeutic procedures. |
其他
| 参考文献： | Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma. Tu L, et al. Mol Cancer, 2010 Apr 16. PMID 20398343.Nuclear assortment of eIF4E coincides with shut-off of host protein synthesis upon poliovirus infection. Sukarieh R, et al. J Gen Virol, 2010 May. PMID 20053821.NAD(P)H quinone-oxydoreductase 1 protects eukaryotic translation initiation factor 4GI from degradation by the proteasome. Alard A, et al. Mol Cell Biol, 2010 Feb. PMID 20028737.HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage. Castell贸 A, et al. PLoS One, 2009 Nov 24. PMID 19956697.The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G. Suzuki Y, et al. J Biol Chem, 2009 Dec 18. PMID 19850929. |
| 保存条件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 标记物： | affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol. |
| 主要序列号： | Q04637 |
| 分子量： | 175491 Da |
| 功能： | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. |
| 规格： | 0.1 mg | 价格： | ¥3300.00 |
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