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eif4e多克隆抗体
- 参考价格： ¥3300.0
- 品 牌： abgent
- 货 号： AE1011a
- 适应物种： 人,小鼠,大鼠
- 应用范围： 免疫印迹,免疫组化,免疫荧光
- 克 隆 性： 多克隆
- 亚 型： Rabbit IgG
- 抗体类型： 一抗
产品概览
| 背景： | All eukaryotic cellular mRNAs are blocked at their 5-prime ends with the 7-methylguanosine cap structure, m7GpppX (where X is any nucleotide). This structure is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export. EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is a 24-kD polypeptide that exists as both a free form and as part of a multiprotein complex termed EIF4F. The EIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis. The other subunits of EIF4F are a 50-kD polypeptide, termed EIF4A (see MIM 601102), that possesses ATPase and RNA helicase activities, and a 220-kD polypeptide, EIF4G (MIM 600495) (Rychlik et al., 1987 [PubMed 3469651]).REFERENCESSox2 is translationally activated by eukaryotic initiation factor 4E in human glioma-initiating cells. Ge Y, et al. Biochem Biophys Res Commun, 2010 Jul 9. PMID 20537983.The virion host shutoff endonuclease (UL41) of herpes simplex virus interacts with the cellular cap-binding complex eIF4F. Page HG, et al. J Virol, 2010 Jul. PMID 20427534.HDAC2 promotes eIF4E sumoylation and activates mRNA translation gene specifically. Xu X, et al. J Biol Chem, 2010 Jun 11. PMID 20421305.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Interaction of Pdcd4 with eIF4E inhibits the metastatic potential of hepatocellular carcinoma. Jiang Y, et al. Biomed Pharmacother, 2010 Jul. PMID 20359850. |
| 其他名字： | eIF-4F 25 kDa subunit; mRNA cap-binding protein; Eukaryotic translation initiation factor 4E, eIF-4E; eIF4E |
| 浓度： | 1mg/ml |
靶点信息
| 基因id： | 1977 |
| 蛋白名： | EIF4E |
| 胞内定位： | Cytoplasm, P-body. |
| 同义词： | EIF4EL1, EIF4F |
应用与保存
| 稀释浓度： | WB~~1:500~1:1000IHC~~1:50~1:100IF~~1:100~200 |
| 注意事项： | EIF4E Antibody (S209) is for research use only and not for use in diagnostic or therapeutic procedures. |
其他
| 参考文献： | Sox2 is translationally activated by eukaryotic initiation factor 4E in human glioma-initiating cells. Ge Y, et al. Biochem Biophys Res Commun, 2010 Jul 9. PMID 20537983.The virion host shutoff endonuclease (UL41) of herpes simplex virus interacts with the cellular cap-binding complex eIF4F. Page HG, et al. J Virol, 2010 Jul. PMID 20427534.HDAC2 promotes eIF4E sumoylation and activates mRNA translation gene specifically. Xu X, et al. J Biol Chem, 2010 Jun 11. PMID 20421305.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Interaction of Pdcd4 with eIF4E inhibits the metastatic potential of hepatocellular carcinoma. Jiang Y, et al. Biomed Pharmacother, 2010 Jul. PMID 20359850. |
| 保存条件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 标记物： | affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol. |
| 主要序列号： | P06730 |
| 分子量： | 25097 Da |
| 功能： | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. |
| 规格： | 0.1 mg | 价格： | ¥3300.00 |
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