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抗人elavl1多克隆抗体
- 参考价格： ¥1100.0 - 2310.0
- 品 牌： abgent
- 货 号： AP8963a
- 适应物种： 人
- 应用范围： 免疫印迹,免疫组化,流式细胞技术
- 克 隆 性： 多克隆
- 亚 型： Rabbit Ig
- 抗体类型： 一抗
产品概览
| 背景： | ELAVL1 is involved in 3'-UTR ARE-mediated MYC stabilization. It binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs.REFERENCESBey,F., et.al., Mol. Gen. Genet. 237 (1-2), 193-205 (1993) |
| 其他名字： | ELAVL1; HUR; ELAV-like protein 1; Hu-antigen R |
靶点信息
| 基因id： | 1994 |
| 蛋白名： | ELAVL1 |
| 胞内定位： | Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2 |
| 同义词： | HUR |
应用与保存
| 稀释浓度： | WB~~1:1000WB~~1:1000IHC~~1:50~100FC~~1:10~50 |
| 注意事项： | ELAVL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
其他
| 参考文献： | Bey,F., et.al., Mol. Gen. Genet. 237 (1-2), 193-205 (1993) |
| 保存条件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 标记物： | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| 主要序列号： | Q15717 |
| 分子量： | 36092 Da |
| 功能： | Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'- UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. |
| 规格： | 400 µl (40 western blots) | 价格： | ¥2310.00 |
| 规格： | 80 µl (8 western blots) | 价格： | ¥1100.00 |
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