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抗人eif4ebp1多克隆抗体
- 参考价格： ¥1100.0 - 2310.0
- 品 牌： abgent
- 货 号： AP12627c
- 适应物种： 人
- 应用范围： 免疫印迹,免疫组化,流式细胞技术
- 克 隆 性： 多克隆
- 亚 型： Rabbit Ig
- 抗体类型： 一抗
产品概览
| 背景： | This gene encodes one member of a family of translationrepressor proteins. The protein directly interacts with eukaryotictranslation initiation factor 4E (eIF4E), which is a limitingcomponent of the multisubunit complex that recruits 40S ribosomalsubunits to the 5' end of mRNAs. Interaction of this protein witheIF4E inhibits complex assembly and represses translation. Thisprotein is phosphorylated in response to various signals includingUV irradiation and insulin signaling, resulting in its dissociationfrom eIF4E and activation of mRNA translation. [provided byRefSeq].REFERENCESShe, Q.B., et al. Cancer Cell 18(1):39-51(2010)Aoyagi, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(6):2640-2645(2010)Naukkarinen, J., et al. PLoS Genet. 6 (6), E1000976 (2010) :Kumar, A., et al. PLoS ONE 5 (1), E8730 (2010) :Villalonga, P., et al. J. Biol. Chem. 284(51):35287-35296(2009) |
| 其他名字： | EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1 |
产品特性
| 预测型适应物种： | Mouse, Rat, Bovine |
靶点信息
| 基因id： | 1978 |
| 蛋白名： | EIF4EBP1 |
应用与保存
| 稀释浓度： | WB~~1:1000WB~~1:1000IHC~~1:10~50FC~~1:10~50 |
| 注意事项： | EIF4EBP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
其他
| 参考文献： | She, Q.B., et al. Cancer Cell 18(1):39-51(2010)Aoyagi, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(6):2640-2645(2010)Naukkarinen, J., et al. PLoS Genet. 6 (6), E1000976 (2010) :Kumar, A., et al. PLoS ONE 5 (1), E8730 (2010) :Villalonga, P., et al. J. Biol. Chem. 284(51):35287-35296(2009) |
| 保存条件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 标记物： | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| 主要序列号： | Q13541 |
| 其他序列号： | Q62622,Q60876,Q0P5A7,NP_004086.1 |
| 分子量： | 12580 Da |
| 功能： | Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. |
| 规格： | 80 µl (8 western blots) | 价格： | ¥1100.00 |
| 规格： | 400 µl (40 western blots) | 价格： | ¥2310.00 |
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