Synthesis, Characterization, and Evaluation of Radiometal-Containing Peptide Nucleic Acids
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Peptide nucleic acids (PNAs) have very attractive properties for applications in nuclear medicine. Because PNAs have high
selectivity for DNA/RNA recognition, resistance to nuclease/protease degradation, and high thermal and radiolytic stabilities,
PNA bioconjugates could transform the areas of diagnostic and therapeutic nuclear medicine. In this book chapter, we report
on the current developments towards the preparation of radiometal-containing PNA constructs and summarize the protocols for
labeling these probes with 99m
Tc, 111
In, 64
Cu, 90
Y, and 177
Lu.
