An Approach Combining Rapid cDNA Amplification and Chemical Synthesis for the Identification of Novel, Cathelicidin-Derived, Antimicrobial Peptides
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Host defense in mammals involves a cooperative effort by a variety of antimicrobial peptides (1 ), which are produced by both phagocyte precursors and some epithelia. They are called on to combat invading pathogens at sites of infection and to help protect mucosal surfaces. Although sharing some common properties, such as a high content of basic residues, these peptides vary widely in both size and primary structure.
