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A subset of SNPs that will represent the majority (90%) of the observed haplotypes but with minimal reduction in power to detect associations determined in earlier will be utilized for this aspect of the proposal. Multiplex and multiplex minisequencing will be utilized to genotype these SNPs in the patients.
A log-linear model embedded within the EM algorithm will be utilized to estimate haplotype frequencies and haplotype-drug induced side effect association.
The analyses assumed Hardy-Weinberg equilibrium but allowed for linkage disequilibrium. Likelihood ratio will be used to assess if haplotype-drug side effect assosication had a better goodness of fit than models assuming no haplotype-drug side effect association. As the likelihood ratio test assessed models rather than particular haplotype ,we will also estimate odds ratios(OR) for each haplotype to quantify the strength and direction of the association of individual haplotypes, using the the more prevalent haplotype as reference.
Can anybody tell me what the sentences above mean, especially the red parts ? Those are very important to me.Thanks a lot!
A log-linear model embedded within the EM algorithm will be utilized to estimate haplotype frequencies and haplotype-drug induced side effect association.
The analyses assumed Hardy-Weinberg equilibrium but allowed for linkage disequilibrium. Likelihood ratio will be used to assess if haplotype-drug side effect assosication had a better goodness of fit than models assuming no haplotype-drug side effect association. As the likelihood ratio test assessed models rather than particular haplotype ,we will also estimate odds ratios(OR) for each haplotype to quantify the strength and direction of the association of individual haplotypes, using the the more prevalent haplotype as reference.
Can anybody tell me what the sentences above mean, especially the red parts ? Those are very important to me.Thanks a lot!
