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        【进展】Rudensky最新Treg review

        丁香园论坛

        1063
        Treg领域的大牛Rudensky在四月的Ann Rev Immunol 关于Treg 分化和功能的最新review。尤其是对于Treg在胸腺和外周分化所需的TCR讯号和因子论述十分详细(老实说这一部分看的不是太懂)。
        虽然没有正面回答,但这篇文章确实解答了本人心中几个疑问,例如Treg能否增殖(能),nTreg和iTreg有无不同(distinct)等。
        希望大家一起学习。



        Regulatory T cells: mechanisms of differentiation and function


        Josefowicz SZ, Lu LF, Rudensky AY.



        Abstract

        The immune system has evolved to mount an effective defense against pathogens and to minimize deleterious immune-mediated inflammation caused by commensal microorganisms, immune responses against self and environmental antigens, and metabolic inflammatory disorders. Regulatory T (Treg) cell-mediated suppression serves as a vital mechanism of negative regulation of immune-mediated inflammation and features prominently in autoimmune and autoinflammatory disorders, allergy, acute and chronic infections, cancer, and metabolic inflammation. The discovery that Foxp3 is the transcription factor that specifies the Treg cell lineage facilitated recent progress in understanding the biology of regulatory T cells. In this review, we discuss cellular and molecular mechanisms in the differentiation and function of these cells.

        目录:
        Introduction
        Foxp3 orchestrates dominant tolerance
        THe indispensable role of Treg cells in immune homeostasis
        Treg cell differentiation in the thymus: roles of TCR and other signals
        Treg cell differentiation in the thymus: the role of cytokines
        Peripheral differentiation of Treg cels: requirements for TCR signaling
        A role for TGF-beta and IL-2 in peripheral differentiation
        Akt activation and peripheral differentiation of Treg cells
        Sites of peripheral Treg cell generation
        Foxp3-dependent Treg cell transcriptional and functional programs
        Foxp3 and its interaction partners

        Role of miRNA in Foxp3+ Treg cells
        Stability and regulation of Foxp3 expression
        Molecuar mechanisms of Treg cell-mediated suppression
        Treg cell-mediated suppression of distinct classes of the imune response
        Concluding remarks
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