【进展】Rudensky最新Treg review
丁香园论坛
1067
Treg领域的大牛Rudensky在四月的Ann Rev Immunol 关于Treg 分化和功能的最新review。尤其是对于Treg在胸腺和外周分化所需的TCR讯号和因子论述十分详细（老实说这一部分看的不是太懂）。
虽然没有正面回答，但这篇文章确实解答了本人心中几个疑问，例如Treg能否增殖（能），nTreg和iTreg有无不同（distinct）等。
希望大家一起学习。
Regulatory T cells: mechanisms of differentiation and function
Josefowicz SZ, Lu LF, Rudensky AY.
Abstract
The immune system has evolved to mount an effective defense against pathogens and to minimize deleterious immune-mediated inflammation caused by commensal microorganisms, immune responses against self and environmental antigens, and metabolic inflammatory disorders. Regulatory T (Treg) cell-mediated suppression serves as a vital mechanism of negative regulation of immune-mediated inflammation and features prominently in autoimmune and autoinflammatory disorders, allergy, acute and chronic infections, cancer, and metabolic inflammation. The discovery that Foxp3 is the transcription factor that specifies the Treg cell lineage facilitated recent progress in understanding the biology of regulatory T cells. In this review, we discuss cellular and molecular mechanisms in the differentiation and function of these cells.
目录：
Introduction
Foxp3 orchestrates dominant tolerance
THe indispensable role of Treg cells in immune homeostasis
Treg cell differentiation in the thymus: roles of TCR and other signals
Treg cell differentiation in the thymus: the role of cytokines
Peripheral differentiation of Treg cels: requirements for TCR signaling
A role for TGF-beta and IL-2 in peripheral differentiation
Akt activation and peripheral differentiation of Treg cells
Sites of peripheral Treg cell generation
Foxp3-dependent Treg cell transcriptional and functional programs
Foxp3 and its interaction partners
Role of miRNA in Foxp3+ Treg cells
Stability and regulation of Foxp3 expression
Molecuar mechanisms of Treg cell-mediated suppression
Treg cell-mediated suppression of distinct classes of the imune response
Concluding remarks
虽然没有正面回答，但这篇文章确实解答了本人心中几个疑问，例如Treg能否增殖（能），nTreg和iTreg有无不同（distinct）等。
希望大家一起学习。
Regulatory T cells: mechanisms of differentiation and function
Josefowicz SZ, Lu LF, Rudensky AY.
Abstract
The immune system has evolved to mount an effective defense against pathogens and to minimize deleterious immune-mediated inflammation caused by commensal microorganisms, immune responses against self and environmental antigens, and metabolic inflammatory disorders. Regulatory T (Treg) cell-mediated suppression serves as a vital mechanism of negative regulation of immune-mediated inflammation and features prominently in autoimmune and autoinflammatory disorders, allergy, acute and chronic infections, cancer, and metabolic inflammation. The discovery that Foxp3 is the transcription factor that specifies the Treg cell lineage facilitated recent progress in understanding the biology of regulatory T cells. In this review, we discuss cellular and molecular mechanisms in the differentiation and function of these cells.
目录：
Introduction
Foxp3 orchestrates dominant tolerance
THe indispensable role of Treg cells in immune homeostasis
Treg cell differentiation in the thymus: roles of TCR and other signals
Treg cell differentiation in the thymus: the role of cytokines
Peripheral differentiation of Treg cels: requirements for TCR signaling
A role for TGF-beta and IL-2 in peripheral differentiation
Akt activation and peripheral differentiation of Treg cells
Sites of peripheral Treg cell generation
Foxp3-dependent Treg cell transcriptional and functional programs
Foxp3 and its interaction partners
Role of miRNA in Foxp3+ Treg cells
Stability and regulation of Foxp3 expression
Molecuar mechanisms of Treg cell-mediated suppression
Treg cell-mediated suppression of distinct classes of the imune response
Concluding remarks
