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        Promoter Analysis of TGF-Responsive Genes by Transient Transfection and Deletional/Mutational Analysis

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        The tranforming growth factor β (TGF-β ) family of cytokines participates in regulating cell growth, morphogenesis, and differentiation by modulating expression of a variety of genes (1 4 ). These gene products broadly cover proteins involved in deposition of an extracellular matrix (ECM), such as fibronectin and its receptor, collagen and collagenase (5 9 ), the proto-oncogene products c-Jun and JunB (10 12 ), the cell-cycle regulators p15 and p21 /Waf/Cip (13 15 ), and proteins involved in apoptotic cell death, such as clusterin (16 ).
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