Capillary Affinity Gel Electrophoresis

Many human genetic diseases are caused by small alterations in DNA sequence of specific gene(s) (1 ,2 . Many different types of DNA mutations and polymorphisms are found to contribute to the alterations in the DNA sequence of disease-causing genes. These polymorphisms include sequence changes, such as the replacement of one or several nucleotides, the deletion or insertion of a sequence, differences in a variable number of tandem repeat locus (VNTR), and the instability in the numbers of tandem copies of microsatellite repeat elements (1 . High-performance technologies need to be developed, for the highly selective recognition of the alterations in the sequence of genes, as new approaches for DNA diagnosis of human diseases are needed for high-throughput analysis