Poly(Lactide-Coglycolide) Microparticles As Vaccine Adjuvants
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Over the last 20 years, the adjuvant effect achieved through the association of antigens with polymeric microparticles has been repeatedly demonstrated (1 ,2 ). Encapsulation of antigens into microparticles, including submicron particles (nanoparticles), promotes their entry into lymph nodes and provides a high local concentration of antigen over an extended time-period. Microparticles also promote the interaction of encapsulated antigens with antigen presenting cells (APCs), e.g., macrophages.
