Liquid Chromatographic Method for Aflatoxin M1 in Milk
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Aflatoxin M1
is the 4-hydroxy derivative of aflatoxin B1
(see
Fig. 1
). Aflatoxin M1
appears in milk and milk products as the direct result of the intake of aflatoxin B1
-contaminated feed by dairy cows (1
). The amount excreted as aflatoxin M1
, as a percentage of aflatoxin B1 in feed, is usually 1-4% (2
), but values as high as 6% have been reported at μg daily intake levels of aflatoxin B1
(3
). The carry-over of aflatoxin B1
to milk may vary largely from animal to animal, from day to day, and from one milking to the next.
Fig. 1.
Chemical structure of aflatoxin M1
.
