CD61分子
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CD61 分子
CD61
常用单克隆抗体或代号： Y2/51,CLB- thromb/1;(VNR- b 链,integrin b 3)
主要表达细胞： Pt,Meg [Pt]
分子质量(kDa)和结构： gp105,血小板GPⅢa,与CD51组成VNR,与CD41组成a Ⅱbb 3
功 能： 血小板凝集和活化
CD61
Aka platelet glycoprotein IIb/IIIa
Receptor for fibrinogen, fibronectin, prothrombin, thrombospondin, vitronectin, plasminogen
Mediates platelet aggregation by binding soluble fibrinogen, forming platelet plug
Defects cause Glanzmann thrombasthenia, an autosomal recessive disorder and the most common inherited platelet disease
Positive staining (normal): platelets, megakaryocytes, myeloid progenitor cells, endothelial cells
Positive staining (disease): AML M7, AML M6 (some), blasts in transient myeloproliferative disorder
Negative staining: AML M0-M5, M6 (most)
Micro images: megakaryoctyes (figures C, D)
