• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        CD66a/CD66b/CD66c/CD66d/CD66e/CD66f/CD67分子

        互联网

        2379
        CD66a/CD66b/CD66c/CD66d/CD66e/CD66f/CD67 分子
         
        CD66a
        常用单克隆抗体或代号: BGP- 1
        主要表达细胞: G,En [M]
        分子质量(kDa)和结构: gp180- 200(胆汁糖蛋白- 1)(IgSF)
        功    能: 嗜同性结合,也可识别CD62E
         
        CD66b
        常用单克隆抗体或代号: MF25.1;(P100,原CD67,CGM6)
        主要表达细胞: G [M]
        分子质量(kDa)和结构: gp95- 100,(GPT连接,IgSF)
        功    能: CEA家族成员
         
        CD66c
        常用单克隆抗体或代号: NCA(无交叉反应抗原)
        主要表达细胞: G [M]
        分子质量(kDa)和结构: gp90- 95(IgSF)
        功    能: CEA家族成员
         
        CD66d
        常用单克隆抗体或代号: CGM1
        主要表达细胞: G [M]
        分子质量(kDa)和结构: Gp30(IgSF)
        功    能: CEA家族成员
         
        CD66e
        常用单克隆抗体或代号: CLB- gran/10(CEA)
        主要表达细胞: G,My,上皮 [M]
        分子质量(kDa)和结构: gp180- 200(IgSF)
        功    能: 粘附,CEA家族成员
         
        CD66f
        常用单克隆抗体或代号: PSG(妊娠特异性抗原)
        主要表达细胞: G,M,Mac [M]
        分子质量(kDa)和结构: gp54-72
        功    能:可能与成功妊娠有关,保护胎儿免受母体免疫系统的损害
         
        CD67
        常用单克隆抗体或代号: 改为CD66b
         
        CD66a
        Aka CEACAM1, biliary glycoprotein, BGP, C-CAM
        Primordial protein of carcinoembryonic antigen (CEA) family
        Cell adhesion molecule capable of activating neutrophils; may regulate CD11/CD18 activity
        Receptor for Neisseria gonorrhea and N. meningitidis
        Downregulated in colorectal, endometrial and hepatocellular carcinomas; supplementation may cause tumor regression in vitro or in rodents
        Downregulated in Gleason grade 4/5 prostate carcinoma, Hum Path 2002;33:290
        Positive staining (normal): granulocytes, epithelial cells, prostate glands and ducts (dense), bile canaliculi between liver cells
        Positive staining (disease): low grade prostatic carcinoma
        Negative staining: prostate carcinoma, Gleason grade 4/5
        Micro images (Hum Path subscribers): Prostate: A-normal, B-Gleason grade 3, C-Gleason grade 4, normal liver (figure F)
         
        CD66b
        Aka CEA gene member 6; formerly CD67
        Capable of activating neutrophils; may regulate CD11/CD18 adhesion activity
        Positive staining (normal): granulocytes
        Positive staining (disease): chronic myelogenous leukemia
         
        CD66c
        Aka noncross reactive antigen (NCA)
        Capable of activating neutrophils; may regulate CD11/CD18 adhesion activity
        Positive staining (normal): granulocytes
         
        CD66d
        Capable of activating neutrophils and functions as a receptor for Neisseria gonorrhea and N. meningitidis
        May play a signaling role and regulate adhesion activity of CD11/CD18 in neutrophils
        Positive staining (normal): granulocytes
         
        CD66e
        Aka CEA, carcinoembryonic antigen
        May play a role in the process of metastasis of cancer cells
        Serum marker of tumor burden, relapse
        Removed by hepatic Kupffer cells via a specific receptor.
        Uses: 85% sensitive, 96% specific for lung adenocarcinomas vs. mesotheliomas; diffuse cylasmic staining with membrane enhancement
        Positive staining (normal): biliary tract, colon (fetal), epithelial cells (apical surfaces), GI adenocarcinomas (endodermally derived), granulocytes, small intestinal crypts; small intestinal goblet cell mucin (not intracylasmic)
        Positive staining (tumors): colonic and lung adenocarcinoma, medullary thyroid carcinoma
        Variable staining: breast carcinoma, endometrial carcinoma, neuroendocrine carcinoma, urothelial carcinoma
        Negative staining: hepatocellular carcinoma, mesothelioma, ovarian carcinoma, prostate adenocarcinoma, renal cell carcinoma, thyroid carcinoma other than medullary
         
        CD66f
        Aka pregnancy-specific glycoprotein
        May be involved in immune regulation, protection of fetus from maternal immune system
        Low levels in maternal blood predict spontaneous abortion
        Positive staining (normal): syncytiotrophoblasts, fetal liver, myeloid cell lines
        Reference: 176390
         
        CD67
        Recognizes non-specific cross-reactive antigens present on granulocytes
        May have role in neutrophil activation
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序