【讨论】请问谁知道这句话中约80%细胞DNA有迹象显示能转录成RNA的文献出处吗？
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“ Strikingly, about 80% of the cell’s DNA showed signs of being transcribed into RNA.”
请问谁知道这句话中约80%细胞DNA有迹象显示能转录成RNA的文献出处吗？
我在这篇文章附的参考文献中未找到：
P. Kapranov, P et al., "Genome-wide transcription and the implications for genomic organization," Nature Rev. Genet. 8, 413 (2007).
E. Birney, et al., "Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project," Nature 447, 799 (2007).
写信问过作者就快一个月也不回我，请大家帮忙！！谢谢！
Shining a Light on the Genome's 'Dark Matter'
http://www.sciencemag.org/content/330/6011/1614.full
Genetic dark matter also loomed large when scientists surveyed exactly
which DNA was being transcribed, or decoded, into RNA. Scientists
thought that most RNA in a cell was messenger RNA generated by
protein-coding genes, RNA in ribosomes, or a sprinkling of other RNA
elsewhere. But surveys by Thomas Gingeras, now at Cold Spring Harbor
Laboratory in New York, and Michael Snyder, now at Stanford University
in Palo Alto, California, found a lot more RNA than expected, as did an
analysis of mouse RNA by Yoshihide Hayashizaki of the RIKEN Omics
Science Center in Japan and colleagues. Other researchers were
skeptical, but confirmation soon came from Ewan Birney of the European
Bioinformatics Institute and the Encyclopedia of DNA Elements project,
which aims to determine the function of every base in the genome. The
2007 pilot results were eye-opening: Chromosomes harbored many
previously unsuspected sites where various proteins bound—possible
hotbeds of gene regulation or epigenetic effects. Strikingly, about 80%
of the cell's DNA showed signs of being transcribed into RNA. What the
RNA was doing was unclear.
请问谁知道这句话中约80%细胞DNA有迹象显示能转录成RNA的文献出处吗？
我在这篇文章附的参考文献中未找到：
P. Kapranov, P et al., "Genome-wide transcription and the implications for genomic organization," Nature Rev. Genet. 8, 413 (2007).
E. Birney, et al., "Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project," Nature 447, 799 (2007).
写信问过作者就快一个月也不回我，请大家帮忙！！谢谢！
Shining a Light on the Genome's 'Dark Matter'
http://www.sciencemag.org/content/330/6011/1614.full
Genetic dark matter also loomed large when scientists surveyed exactly
which DNA was being transcribed, or decoded, into RNA. Scientists
thought that most RNA in a cell was messenger RNA generated by
protein-coding genes, RNA in ribosomes, or a sprinkling of other RNA
elsewhere. But surveys by Thomas Gingeras, now at Cold Spring Harbor
Laboratory in New York, and Michael Snyder, now at Stanford University
in Palo Alto, California, found a lot more RNA than expected, as did an
analysis of mouse RNA by Yoshihide Hayashizaki of the RIKEN Omics
Science Center in Japan and colleagues. Other researchers were
skeptical, but confirmation soon came from Ewan Birney of the European
Bioinformatics Institute and the Encyclopedia of DNA Elements project,
which aims to determine the function of every base in the genome. The
2007 pilot results were eye-opening: Chromosomes harbored many
previously unsuspected sites where various proteins bound—possible
hotbeds of gene regulation or epigenetic effects. Strikingly, about 80%
of the cell's DNA showed signs of being transcribed into RNA. What the
RNA was doing was unclear.
我写信给了science上这篇报道的作者。作者很快就回信说 ：That came from interviews I did for the story.
freecell wrote:
我写信给了science上这篇报道的作者。作者很快就回信说 ：That came from interviews I did for the story.
谢谢freecell，怎么这个作者没回复我呢。这么说这是作者做的采访性或面谈性的总结记录，像这样结论性的东西没有明确的工作支持，能这样下结论？可靠吗？
请问各位有对这方面了解的吗？到底人体中是否有将近80%细胞DNA转录成RNA？
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