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        【资源】G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity

        丁香园论坛

        514


        Publisher: Wiley-VCH
        Number Of Pages: 304
        Publication Date: 2006-01-09
        Sales Rank: 488335
        ISBN / ASIN: 3527308199
        EAN: 9783527308194
        Binding: Hardcover
        Manufacturer: Wiley-VCH
        Studio: Wiley-VCH
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        Book Description:

        With its particular emphasis on the constitutive activity of G-protein-coupled receptors (GPCRs)s, this book comprehensively discusses an important biological process that has not yet been covered in such depth in any other existing books on GPCRs. The international team of highly distinguished authors addresses in detail current models and concepts, to introduce medicinal chemists, physiologists, pharmacologists, and medical researchers into the advances in the understanding of GPCR activation and constitutive activity. In addition, the book provides an overview on methods of investigating constitutive GPCR activity. The text is well illustrated by selected experimental data and schemes._The chaptes are all cross-referenced with each other and cover general mechnisms, methodological approaches and cover selected important GPCR sysstems, the consequences for drug action, including, side effects, and rational drug design for GPCR targets. A highly recommended reference for researchers in academia and industry.

        authors addresses in detail current models and concepts, so as to introduce pharmaceutical chemists, physiologists and medical researchers to the advances in the understanding of GPCR activation and constitutive activity, and provides an overview of the methods of investigating GPCR activity. The text is backed by abundant case studies and methodological advice for analyzing GPCRs, covering selected pharmacologically relevant GPCR systems, the consequences for drug action, including unwanted side effects, and rational drug design for GPCR targets.
        A highly practical reference for researchers in academia and industry.

        2.37 MB
        http://rapidshare.com/files/34090360/Sei_GPrCoReaDrTa.rar
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