• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Determination of Peak Serum Levels and Immune Response to the Humanized Anti-Ganglioside Antibody-Interleukin-2 Immunocytokine

        互联网

        1160
        Tumor reactive monoclonal antibodies (mAb) have been developed and tested as anti-tumor therapy. Some mAb have shown efficacy and are now approved as clinical cancer therapy. The mechanism of action for the antitumor effect includes tumor cell destruction by effector cells with Fc receptors such as natural killer (NK) cells and macrophages. These cells recognize the mAb binding to the tumor cells and mediate antibody-dependent cellular cytotoxicity (ADCC). Enhanced ADCC is mediated by effector cells that have been activated by exposure to the cytokine IL-2 (1 ). Thus, in murine models, enhanced tumor destruction is produced when tumor bearing animals are treated with a combination of antitumor mAb and IL-2 (2 ). Clinical testing of mAb and IL-2 is underway.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序