GMP级人源化CD3抗体 (humanized OKT3,

产品名称：Human CD3 (humanized OKT3) Antibody-Human IgG4 (GMP-grade)
经验证的应用：FCM, Func/A
交叉反应：Reacts with: Human
特异性：Human CD3 epsilon/CD3e
制备方法：Human CD3 (humanized OKT3) Antibody is a humanized antibody of Orthoclone OKT3 (GMP-grade procution). Orthoclone OKT3 is an immunosuppressant drug given to reduce acute rejection in patients with organ transplants. It is a monoclonal antibody targeted at the CD3 receptor, a membrane protein on the surface of T cells. It was the first monoclonal antibody to be approved for clinical use in humans.
来源：Human IgG4 Clone #H001
缓冲液：0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0
偶联物：Unconjugated
内毒素：< 0.5 EU/mg
状态：Liquid
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

在CAR-T细胞免疫治疗过程中，从患者外周血中收集、分离得到的T细胞用于改造之前需要先进行活化。最常见的用于T细胞体外活化的是CD3抗体和CD28抗体 。义翘神州已开发GMP级别的CD3以及CD28单克隆激活抗体，纯度高，活性高，超低内毒素（<0.5 EU/mg），经细胞水平验证，可有效激活培养T细胞，更好地助力CAR-T细胞治疗药物开发和生产。

CAR-T细胞制备T细胞激活

GMP级CD3（OKT3）单克隆抗体 （Cat#: GMP-10977-H001）

• 严格按照GMP规范生产，质量标准参照《中国药典》2020版四部
• 高纯度，超低内毒素（<0.5 EU/mg），高生物活性
• 15项质控指标，涵盖支原体、异常毒性、宿主DNA残留、HCP残留等
• 高批间一致性，现货供应

Effect of human CD3 (humanized OKT3) antibody on the proliferation and IFN-gamma secretion of CD4⁺ T cells.

GMP级CD28单克隆抗体（Cat#: GMP-11524-H001）

• 严格按照GMP规范生产，质量标准参照《中国药典》2020版四部
• 高活性，高纯度，高稳定性
• 15项质控指标，涵盖支原体、异常毒性、宿主DNA残留、HCP残留等
• 高安全性，具有无菌、无支原体、超低内毒素（<0.5 EU/mg）等特性

Effect of human CD28 antibody on stimulating IL-2 secretion of CD4⁺ T cells co-activated with CD3 antibody.