• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Typing Alleles of HLA-DM

        互联网

        725
        Human leukocyte antigen DM (HLA-DM) is a major histocompatibility complex (MHC) class II-like molecule that facilitates antigen processing by catalyzing the exchange of invariant chain-derived peptides (CLIP) from class II molecules for antigenic peptides. The genes encoding HLA-DM, HLA-DMA and -DMB , are located in tandem in the class II region of the MHC, between HLA-DP and HLA-DQ loci (1 ). HLA-DMA and -DMB products co-localize with HLA-DR in the specialized acidic MHC class II compartment (MIIC) of antigen presenting cells, but no expression of these molecules is detectable at the cell surface. The interaction of DM with class II also aids in the subsequent rapid loading of high-affinity antigen-derived peptides into the MHC class II groove. There is now accumulating evidence that HLA-DM functions as a peptide editor that removes low-stability ligands and skews the class II peptide repertoire toward high-stability ligands (2 4 ). Because of their role in antigen processing and their location within the class II region of the MHC, these genes have attracted attention as possible disease susceptibility loci.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序