CD47/CD47R分子
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CD47/CD47R 分子
CD47
常用单克隆抗体或代号： BRIC126,CIKM1
主要表达细胞： 广泛 [AS]
分子质量(kDa)和结构： gp47,N连接葡萄糖
功 能： 粘附分子相关信号分子
CD47R
常用单克隆抗体或代号：(为原CDw149)MEM―33
主要表达细胞：广泛[NL]
CD47
Aka integrin associated protein (IAP); one of many thrombospondin receptors
Similar to Rh-antigen
May interact with integrins and mediate intracellular calcium increase during cell adhesion
May help macrophages distinguish self from foreign substances
May have role in giant cell creation from macrophage fusion
Positive staining (normal): hemaoietic cells, epithelial cells, endothelial cells, fibroblasts, mesenchymal cells
Positive staining (disease): tumor cell lines
CD47R
Aka Rh related antigen
Similar to Rh-antigen; may interact with integrins
Previously CDw149
