Y Receptors Characterized by RT-PCR: Distribution in Rat Intestine
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Receptors for peptide YY (PYY) were discovered in the rat small intestine epithelium (1
) and were defined as PYY-preferring
because they display a slightly higher affinity for PYY than for neuropeptide Y (NPY). In contrast, they have a very low
affinity for pancreatic polypeptide (PP). They are exclusively present in proliferative crypt cells and appear to be quenched
when epithelial cells migrate onto the villi, where they stop to divide and differentiate into mature enterocytes (2
). They are not expressed by colonic epithelium (1
). Altogether, these observations support the idea that cryptic PYY-preferring receptors may be responsible for the antisecretory
actions of PYY and NPY in the small intestine (3
).
