Binding of SV40 Large T Antigen to the Retinoblastoma Susceptibility Gene Product and Related Proteins

SV40 large T antigen (T-ag) is an oncoprotein that induces transformation of cells through the binding and inactivation of the p53 tumor suppressor protein and the retinoblastoma family of proteins. This chapter focuses on the interaction of T-ag with the product of the retinoblastoma susceptibility gene (pRB), and two related proteins, p107 and p130 (1 -3 ).