Less common disorders:E

互联网2013-09-05

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佚名

DISEASE AND CAUSES	PATHOPHYSIOLOGY	SIGNS AND SYMPTOMS
*Endocarditis*
Infection due to bacteria, viruses, fungi, rickettsiae, and parasites	Endothelial damage allows microorganisms to adhere to the surface where they proliferate and promote the propagation of endocardial vegetation.	Weakness and fatigue Weight loss, fever, night sweats, and anorexia Arthralgia, splenomegaly, and new systolic murmur
*Epidermolysis bullosa*
Cause unknown Nonscarring forms result from an autosomal dominant inheritance, except for junctional epidermolysis bullosa (recessively inherited) and dystrophic epidermolysis bullosa (results from X-linked recessive inheritance)	Blisters occur from frictional trauma or heat; prognosis depends on severity. Fatal in infant and child, but becomes less severe as patient matures.	Blisters appear on hands, feet, knees, or elbows Sloughing of large areas of newborn skin Blistering occurs in GI, respiratory, or genitourinary tracts Eyelid blisters, conjunctivitis, adhesions, and corneal opacities
*Esophageal varices*
Portal hypertension	Shunting of blood to the venae cavae due to portal hypertension leads to dilatation of esophageal veins.	Hemorrhage and subsequent hypotension Compromised oxygen supply Altered level of consciousness

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