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        Less common disorders:E

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        DISEASE AND CAUSES PATHOPHYSIOLOGY SIGNS AND SYMPTOMS
        Endocarditis  
        • Infection due to bacteria, viruses, fungi, rickettsiae, and parasites
        Endothelial damage allows microorganisms to adhere to the surface where they proliferate and promote the propagation of endocardial vegetation.
        • Weakness and fatigue
        • Weight loss, fever, night sweats, and anorexia
        • Arthralgia, splenomegaly, and new systolic murmur
        Epidermolysis bullosa  
        • Cause unknown
        • Nonscarring forms result from an autosomal dominant inheritance, except for junctional epidermolysis bullosa (recessively inherited) and dystrophic epidermolysis bullosa (results from X-linked recessive inheritance)
        Blisters occur from frictional trauma or heat; prognosis depends on severity. Fatal in infant and child, but becomes less severe as patient matures.
        • Blisters appear on hands, feet, knees, or elbows
        • Sloughing of large areas of newborn skin
        • Blistering occurs in GI, respiratory, or genitourinary tracts
        • Eyelid blisters, conjunctivitis, adhesions, and corneal opacities
        Esophageal varices  
        • Portal hypertension
        Shunting of blood to the venae cavae due to portal hypertension leads to dilatation of esophageal veins.
        • Hemorrhage and subsequent hypotension
        • Compromised oxygen supply
        • Altered level of consciousness

         

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