【经典文献】balb/c小鼠MHC I和II类表位的分析(程序及网站介绍)
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题目:PREDBALB/c: a system for the prediction of peptide binding to H2d molecules, a haplotype of the BALB/c mouse
出处：Nucleic Acids Research,
作者：Guang Lan Zhang1,2, Kellathur N. Srinivasan3,4, Anitha Veeramani1,J. Thomas August3 and Vladimir Brusic1,5~undefined
文献介绍及评论：
PREDBALB/c is a computational system that predicts peptides binding to the major histocompatibility complex-2 (H2d) of the BALB/c mouse, an important laboratory model organism. The predictions include the complete set of H2d class I (H2-Kd, H2-Ld and H2-Dd) and class II (I-Ed and I-Ad) molecules. The prediction system utilizes quantitative matrices, which were rigorously validated using experimentally determined binders and non-binders and also by in vivo studies using viral proteins. The prediction performance of PREDBALB/c is of very high accuracy. To our knowledge, this is the first online server for the prediction of peptides binding to a complete set of major
histocompatibility complex molecules in a model organism (H2d haplotype). PREDBALB/c is available at http://antigen.i2r.a-star.edu.sg/predBalbc/.
这是目前唯一的网上可以分析Blab/c 小鼠 抗原表位的程序, 可以到 http://antigen.i2r.a-star.edu.sg/predBalbc/ 进行分析. 文章介绍说可以进行H2d I类 (H2-Kd, H2-Ld and H2-Dd)和 II类 (I-Ed and I-Ad)表位的分析,且有很高的准确律.
不过,无论如何,这个程序为我们选择多肽序列时,提供了更多的依据.
出处：Nucleic Acids Research,
作者：Guang Lan Zhang1,2, Kellathur N. Srinivasan3,4, Anitha Veeramani1,J. Thomas August3 and Vladimir Brusic1,5~undefined
文献介绍及评论：
PREDBALB/c is a computational system that predicts peptides binding to the major histocompatibility complex-2 (H2d) of the BALB/c mouse, an important laboratory model organism. The predictions include the complete set of H2d class I (H2-Kd, H2-Ld and H2-Dd) and class II (I-Ed and I-Ad) molecules. The prediction system utilizes quantitative matrices, which were rigorously validated using experimentally determined binders and non-binders and also by in vivo studies using viral proteins. The prediction performance of PREDBALB/c is of very high accuracy. To our knowledge, this is the first online server for the prediction of peptides binding to a complete set of major
histocompatibility complex molecules in a model organism (H2d haplotype). PREDBALB/c is available at http://antigen.i2r.a-star.edu.sg/predBalbc/.
这是目前唯一的网上可以分析Blab/c 小鼠 抗原表位的程序, 可以到 http://antigen.i2r.a-star.edu.sg/predBalbc/ 进行分析. 文章介绍说可以进行H2d I类 (H2-Kd, H2-Ld and H2-Dd)和 II类 (I-Ed and I-Ad)表位的分析,且有很高的准确律.
不过,无论如何,这个程序为我们选择多肽序列时,提供了更多的依据.
