数据库

Abstract Table of Contents Figures Literature Cited Abstract The laboratory rat, Rattus norvegicus, is an important model of human health and disease, and experimental findings in the rat have relevance to human physiology and disease. The

Abstract Table of Contents Figures Literature Cited Supplementary Materials Abstract The field of molecular evolution, which includes genome evolution, is devoted to finding variation within and bet

Abstract Table of Contents Materials Figures Literature Cited Abstract Phosphorylation of substrates by protein kinases regulates a myriad of cellular processes, ranging from proliferation and migration t

Abstract Table of Contents Materials Figures Literature Cited Abstract The amount of sequence obtained by modern sequencing machines greatly exceeds the sequencing depth requirements of many experiments,

Abstract Table of Contents Materials Figures Literature Cited Abstract PolyPhen?2 (Polymorphism Phenotyping v2), available as software and via a Web server, predicts the possible impact of amino acid subs

Abstract Table of Contents Figures Literature Cited Abstract Admixture mapping is a powerful method of gene mapping for diseases or traits that show differential risk by ancestry. Admixture mapping has been applied most often to African Am

Abstract Table of Contents Literature Cited Abstract In this unit we discuss the importance of implementing a data management system for research animal colonies. We focus on drivers such as ethical considerations, cost, and data integrity. We also discuss keys to effective

Abstract Table of Contents Literature Cited Abstract Mass spectrometry has become a major tool in the study of proteomes. The analysis of proteolytic peptides and their fragment ions by this technique enables the identification and quantitation of the precursor proteins in

Abstract Table of Contents Figures Literature Cited Abstract Although individual tumors show surprisingly diverse genomic alterations, these events tend to occur in a limited number of pathways, and alterations that affect the same pathway

Abstract Table of Contents Figures Literature Cited Abstract The constant improvement of high?throughput technologies has led to a great increase in generated data per single experiment. Pathway analysis is a widespread method to understan

Abstract Table of Contents Figures Literature Cited Abstract Human Proteinpedia (http://www.humanproteinpedia.org) is a publicly available proteome repository for sharing human protein data derived from multiple experimental platforms. It

Abstract Table of Contents Materials Figures Literature Cited Abstract The cell is a spatially organized system whose function emerges from the complex interaction of molecular components. Such local inte

Abstract Table of Contents Figures Literature Cited Abstract Modern genetic association studies, using genome?wide genotype data, are often underpowered. Meta?analyses of multiple studies performing genome?wide genotyping improve power and

Abstract Table of Contents Figures Literature Cited Abstract The essence of bioinformatics is dealing with large quantities of information. Whether it be sequencing data, microarray data files, mass spectrometric data (e.g., fingerprints),

Abstract Table of Contents Figures Literature Cited Abstract The iPlant Collaborative's Discovery Environment is a unified Web portal to many bioinformatics applications and analytical workflows, including various methods of phylogenetic a

Abstract Table of Contents Figures Literature Cited Abstract Sequence similarity searching, typically with BLAST, is the most widely used and most reliable strategy for characterizing newly determined sequences. Sequence similarity searche

Abstract Table of Contents Figures Literature Cited Abstract The iPlant Collaborative is an academic consortium whose mission is to develop an informatics and social infrastructure to address the ?grand challenges? in plant biology. Its cy

Abstract Table of Contents Materials Figures Literature Cited Abstract Recent studies highlight the importance of translational control in determining protein abundance, underscoring the value of measurin

Abstract Table of Contents Literature Cited Abstract Although genome?wide association studies have been successful in detecting associations with common variants, there is currently an increasing interest in identifying low?frequency and rare variants associated with c ...

Abstract Table of Contents Figures Literature Cited Abstract Although the identification of protein interactions by high?throughput methods progresses at a fast pace, ?interactome? datasets still suffer from high rates of false positives a