生物信息学技术

Abstract Table of Contents Figures Literature Cited Abstract Sequence similarity searching, typically with BLAST, is the most widely used and most reliable strategy for characterizing newly determined sequences. Sequence similarity searche

Abstract Table of Contents Figures Literature Cited Abstract The iPlant Collaborative is an academic consortium whose mission is to develop an informatics and social infrastructure to address the ?grand challenges? in plant biology. Its cy

Abstract Table of Contents Materials Figures Literature Cited Abstract Recent studies highlight the importance of translational control in determining protein abundance, underscoring the value of measurin

Abstract Table of Contents Literature Cited Abstract Although genome?wide association studies have been successful in detecting associations with common variants, there is currently an increasing interest in identifying low?frequency and rare variants associated with c ...

Abstract Table of Contents Figures Literature Cited Abstract Although the identification of protein interactions by high?throughput methods progresses at a fast pace, ?interactome? datasets still suffer from high rates of false positives a

Abstract Table of Contents Figures Literature Cited Abstract An overview of computer simulation techniques as applied to nucleic acid systems is presented. This unit discusses methods used to treat energy and to sample representative confi

Abstract Table of Contents Figures Literature Cited Abstract This unit is the first in a series of four units covering the analysis of nucleic acid structure by molecular modeling. The unit provides an overview of the computer simulation o

Abstract Table of Contents Materials Literature Cited Abstract Selective 2? hydroxyl acylation analyzed by primer extension (SHAPE) provides a means to investigate RNA structure with better resolution and higher throughput than has been po

Abstract Table of Contents Materials Figures Literature Cited Abstract Whole?genome sequencing (WGS) has been used in many invertebrate model organisms as an efficient tool for mapping and identification

Abstract Table of Contents Figures Literature Cited Abstract Over the last several years, next?generation sequencing (NGS) has transformed genomic research through substantial advances in technology and reduction in the cost of sequencing,

Abstract Table of Contents Figures Literature Cited Abstract The analysis of genome?scale sequence data can be defined as the interrogation of a complete set of genetic instructions in a search for individual loci that produce or contribut

Abstract Table of Contents Materials Figures Literature Cited Abstract High?density SNP genotyping technology provides a low?cost, effective tool for conducting Genome Wide Association (GWA) studies. The

Abstract Table of Contents Figures Literature Cited Abstract LipidXplorer is an open?source software kit that supports the identification and quantification of molecular species of any lipid class detected by shotgun experiments performed

Abstract Table of Contents Figures Literature Cited Abstract This unit describes how to use BWA and the Genome Analysis Toolkit (GATK) to map genome sequencing data to a reference and produce high?quality variant calls that can be used in

Abstract Table of Contents Figures Literature Cited Abstract Cloud Computing refers to distributed computing platforms that use virtualization software to provide easy access to physical computing infrastructure and data storage, typically

Abstract Table of Contents Figures Literature Cited Abstract Protein sequence similarity searching programs like BLASTP, SSEARCH, and FASTA use scoring matrices that are designed to identify distant evolutionary relationships (BLOSUM62 for

Abstract Table of Contents Materials Figures Literature Cited Abstract RNA annotation and mapping of promoters for analysis of gene expression (RAMPAGE) is a method that harnesses highly specific sequenci

Abstract Table of Contents Figures Literature Cited Abstract This unit presents an overview of computer simulation techniques as applied to nucleic acid systems, ranging from simple in vacuo molecular modeling techniques to more complete a

Abstract Table of Contents Materials Figures Literature Cited Abstract The PepArML meta?search peptide identification platform for tandem mass spectra provides a unified search interface to seven search e

Abstract Table of Contents Figures Literature Cited Abstract The identification of protein post?translational modifications (PTMs) is an increasingly important component of proteomics and biomarker discovery, but very few tools exist for p