生物信息学技术

Abstract Table of Contents Materials Figures Literature Cited Abstract The use of rodents to model neuromuscular diseases necessitates assessment of neuromuscular function to monitor disease progression.

Abstract Table of Contents Materials Figures Literature Cited Abstract Here we describe a step?by?step method for vital imaging of neuromuscular junctions (NMJ) and axons using fiber?optic confocal microe

Abstract Table of Contents Materials Figures Literature Cited Abstract The completion of genome sequencing in humans and mice has opened new opportunities to study the relationship between gene expression

Abstract Table of Contents Materials Figures Literature Cited Abstract Although alternative, noninvasive methods are being developed, current research on rodent sleep still almost exclusively relies on re

Abstract Table of Contents Materials Figures Literature Cited Abstract Harnessing the natural ability of viruses to infect post?mitotic cells such as neurons has provided an explosion of new methods to ma

Abstract Table of Contents Materials Figures Literature Cited Abstract The metabolome is the terminal downstream product of the genome and consists of the total complement of all the low?molecular?weight

Abstract Table of Contents Materials Figures Videos Literature Cited Abstract Live imaging is critical to determining the dynamics and spatial interactions of cells within

Abstract Table of Contents Materials Figures Literature Cited Abstract Understanding the metabolic pathway and excretion mechanisms governing the disposition of a compound is essential to the safe use of

Abstract Table of Contents Materials Figures Literature Cited Abstract In vitro?differentiated embryonic stem (ES) cells comprise a useful source for cell replacement therapy, but the efficiency and safet

Abstract Table of Contents Materials Figures Literature Cited Abstract The factors that regulate the switch from adult neural stem cell (aNSC) quiescence to active proliferation are poorly understood. Her

Abstract Table of Contents Materials Figures Literature Cited Abstract We have developed an improved cardiomyocyte differentiation protocol where we stabilized embryoid bodies (EB) in serum? and insulin?f

Abstract Table of Contents Figures Literature Cited Abstract This overview first summarizes the last decade of continuous developments and improvements in pre?clinical imaging methods that are now essential tools for in vivo evaluation of

Abstract Table of Contents Figures Literature Cited Abstract Good science and good animal care go hand in hand. A sick or distressed animal does not produce the reliable results that a healthy and unstressed animal produces. This unit desc

Abstract Table of Contents Materials Figures Literature Cited Abstract Bronchoalveolar lavage (BAL) is a simple technique commonly used in humans to sample the contents of the epithelial lining fluid and

Abstract Table of Contents Literature Cited Abstract Historically, spontaneous mutations in mice have served as valuable models of heritable human diseases, contributing substantially to our understanding of both disease mechanisms and basic biological pathways. While ad ..

Abstract Table of Contents Literature Cited Abstract Overlapping characteristics between human depressive phenotypes and mouse behaviors has led to the creation of mouse models that aim to investigate the pathophysiology and treatment of unipolar depression. Behavioral te .

Abstract Table of Contents Materials Figures Literature Cited Abstract The mouse is one of the most important mammalian model systems for studying host?pathogen?interactions during influenza A virus infec

Abstract Table of Contents Materials Figures Literature Cited Abstract Habit formation refers to the process by which goal?directed behavior becomes automatized and less sensitive to changes in the value

Abstract Table of Contents Materials Figures Literature Cited Abstract Assessing abuse liability is a crucial step in the development of a novel chemical entity (NCE) with central nervous system (CNS) act

Abstract Table of Contents Literature Cited Abstract The focus of this overview is on the animal models of obesity most commonly utilized in research. The models include monogenic models in the leptin pathway, polygenic diet?dependent models, and, in particular for their hi