Amitivir,111393-84-1

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Amitivir

CAS No. : 111393-84-1

MCE 国际站：Amitivir

产品活性：Amitivir (LY217896) 是一种噻二唑衍生物，对正粘病毒和副粘病毒具有广泛的抗病毒活性。Amitivir 对 A 和 B 型流感病毒 (influenza A/B) 有效。

研究领域：Anti-infection

作用靶点：Influenza Virus

In Vitro: The mean 50% inhibitory concentration of Amitivir inhibits six strains of type A influenza (A/Russia, A/Brazil/11/78, A/Ann Arbor/1/57, A/Port Chalmers/1/73, A/Hong Kong/8/68 and A/X-15) ranged from 0.37 to 1.19 μg/ml. The mean 50% inhibitory concentration of Amitivir inhibits four strains of influenza B virus (B/Maryland/11/59, B/GreatLakes/1739/54, B/Singapore/3/64, B/Lee/40) ranged from 0.75 to 1.54 μg/ml.

In Vivo: Amitivir (LY 217896) (9 mg/m² of body surface area per day) administered in the diet, in the drinking water, by oral gavage, by intraperitoneal injection, or by aerosolization was well tolerated and protected CD-1 mice infected with a lethal dose of influenza A or B virus.

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