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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
UBX1967
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1391107-89-3
- 规格：
10 mM * 1 mL///1 mg
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BM-1197
CAS No. : 1391107-89-3
MCE 国际站：BM-1197
产品活性：BM-1197 (UBX1967) 是一种有效的和选择性的 Bcl-2/Bcl-xL 的双重抑制剂，抑制 Bcl-2 和 Bcl-xL 的 IC50 值分别为 3.5 nM 和 5.2 nM。BM-1197 在体外和体内均表现出抗肿瘤作用。
研究领域：Apoptosis
作用靶点：Bcl-2 Family
In Vitro: BM-1197 (2-2000 nM; 3 d) has marginal cytotoxicity against wild-type mouse embryonic fibroblast (MEF) cells but exerts potent growth-inhibitory activity in the MCL1−/− cells.
BM-1197 shows potent growth-inhibitory activities in 7 small cell lung cancer (SCLC) cell lines with IC50s <100 nM, moderate activity in 3 SCLC cell lines with IC50s of ∼600 nM and weak activity in 2 SCLC cell lines with IC50s >2000 nM.
BM-1197 (100 nM; 16 h) potently induces apoptosis in H146 cells.
BM-1197 (100 nM; 2 h) disrupts the association between Bcl-xl and Puma or Bim in H146 cells.
BM-1197 (100 nM; 0.5-2 h) induces Bax translocation, and it (3-30 nM; 2 h) induces cytochrome c release in H146 cells.
In Vivo: BM-1197 (10 mg/kg; i.v. daily 5 days per week for 2 weeks) results in rapid and complete tumor regression in all 8 mice in H146 and H1963 tumor model.
BM-1197 (15 mg/kg; i.v.) causes thrombocytopenia in mice but the effect is reversible even at highly efficacious doses.
BM-1197 (10 mg/kg; i.v. qd) exerts a strong anti-tumor effect and is well tolerated in OCI-Ly8 xenograft models.
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文献和实验Adrenal chromaffin granule (chromaffin vesicle) preparation
chromaffin granule prep on a sucrose gradient. Barbosa JA, Gill BM, Takiyyuddin MA, O'Connor DT: Chromogranin A: posttranslational modifications in secretory granules. Endocrinology 128:174-190, 1991. O'Connor DT, Klein RL, Thureson-Klein AK
Isolation of Retroelement from Plant Genomic DNA (PCR法从植物寻找逆转录元件)
are ubiquitous among plants. Proc.Natl.Acad.Sci.USA 89: 7124-7128 Hirochika H, Hirochika R. 1993. Tyl-copia group retrotransposons as ubiquitous components of plant genomes. Jpn J Genet 68: 35-46; Hirochika H, Fukuchi A, Kikuchi F. 1992. Retrotransposon
; one patient did not use the AL- SENSE according to instructions, and one patient had vaginal bleeding while using the panty-liner). Gestational age and demographic data follow for the 103 valid cases: 92 (89.4%) of the participants were 36
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