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Please store the product under the recommended conditions in the Certificate of Analysis.
- 英文名：
EX-1314 dihydrochloride
- 库存：
货期：电询
- 供应商：
MedChemExpress LLC
- CAS号：
1469750-46-6
- 规格：
电询
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BMS-604992 dihydrochloride
CAS No. : 1469750-46-6
MCE 国际站：BMS-604992 dihydrochloride
产品活性：BMS-604992 (EX-1314) dihydrochloride 是一种选择性的口服活性小分子 growth hormone secretagogue receptor (GHSR) 激动剂。BMS-604992 dihydrochloride 具有高亲和力 (ki=2.3 nM) 和强大的功能活性 (EC50=0.4 nM)。BMS-604992 dihydrochloride 能刺激啮齿动物进食。
研究领域：GPCR/G Protein
作用靶点：GHSR
In Vitro: BMS-604992 exhibits high-affinity binding (Ki=2.3 nM) and potent functional activity (EC50=0.4 nM) for ghrelin receptor.
In Vivo: BMS-604992 (500 μg/kg; i.p.; 5 minutes) results in a significant increase in gastric emptying compared with vehicle-treated mice.
BMS-604992 (1~1000 mg/kg; p.o.; 1 hour) Shows a dose-linear increase in plasma concentrations at the 1 hour time point and elicits a dose-responsive increase in food intake relative to vehicle-treated controls, with a minimum effective dose of approximately 10 mg/kg.
BMS-604992 (300 mg/kg; p.o.; 5~20 minutes) produces a significant difference at the 5 minutes time point.
BMS-604992 (500 μg/kg; i.p.; 4 hours) increases food intake approximately 2-fold compared with vehicle-treated controls.
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