AS1269574,330981-72-1

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AS1269574

CAS No. : 330981-72-1

MCE 国际站：AS1269574

产品活性：AS1269574 是一种有效的，具有口服活性的 GPR119 激动剂，在表达人 GPR119 的 HEK293 细胞中 EC₅₀ 为 2.5 μM。AS1269574 激活 TRPA1 阳离子通道，刺激胰高血糖素样肽-1 (GLP-1) 分泌。AS1269574 仅在高糖条件下特异性诱导胰腺 β 细胞分泌葡萄糖依赖性胰岛素。AS1269574 对 2 型糖尿病研究具有潜力。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Membrane Transporter/Ion Channel

作用靶点：GPR119  |  TRP Channel

In Vivo: AS1269574 sgnificantly reduced the blood glucose AUC after 2 h (AUC_0-2h) of administration.

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