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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, protect from light
- 英文名：
Ametycine
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
50-07-7
- 规格：
5 mg/10 mg/50 mg/100 mg/200 mg
| 规格： | 5 mg | 产品价格： | ￥493.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥780.0 |
| 规格： | 50 mg | 产品价格： | ￥2000.0 |
| 规格： | 100 mg | 产品价格： | ￥3000.0 |
| 规格： | 200 mg | 产品价格： | ￥4850.0 |
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Mitomycin C
CAS No. : 50-07-7
MCE 国际站：Mitomycin C
产品活性：Mitomycin C (Ametycine) 是一种 DNA 交联剂 (DNA cross-linking agent)，诱导 DNA 损伤。Mitomycin C 是一种抗肿瘤化合物和抗生素，可有效的抑制 DNA 合成 (DNA synthesis)。Mitomycin C 是一种 ADC 毒性分子 (ADC Cytotoxin)，可以诱导凋亡 (Apoptosis) 作用。
研究领域：Cell Cycle/DNA Damage | Antibody-drug Conjugate/ADC Related | Anti-infection | Apoptosis
作用靶点：DNA Alkylator/Crosslinker | DNA/RNA Synthesis | ADC Cytotoxin | Bacterial | Apoptosis | Antibiotic
In Vitro: The HCT116 (p53-/-) cells are minimally sensitive to either Mitomycin C (Ametycine) or TRAIL alone. However, surprisingly, combination treatment with MMC and TRAIL decreases cell viability significantly. Although Mitomycin C and TRAIL alone are moderately effective, Mitomycin C substantially enhances the effect of TRAIL on suppression of the cell proliferation. Mitomycin C and TRAIL treatment alone induces 9.5% and 35.0% apoptosis, respectively. However, combination treatment with Mitomycin C and TRAIL enhances apoptosis to 66.6%.
?Mitomycin C is a cytotoxic chemotherapeutic agent that causes DNA damage in the form of DNA cross-links as well as a variety of DNA monoadducts and is known to induce p53.
In Vivo: Mice bearing xenografted HCT116 (p53-/-) colon tumors and HT-29 colon tumors are treated with Mitomycin C (Ametycine; i.p., 1 mg/kg) and TRAIL (i.v., 100 μg) every other day. Animals are treated with 10 consecutive cycles of the combination therapy regimen. The combination therapy suppresses tumor growth significantly and does not impact the weight of the mice, indicating that the therapeutic combination of Mitomycin C and TRAIL is well-tolerated and has anti-tumor activity in vivo.
?Intravesical Mitomycin C instillations has an effect on body weight. After 3 consecutive weekly instillations of 1 mg/mL Mitomycin C there is almost no weight gain, whereas rats in the other 3 groups has a statistically significant weight gain compared with MMC treated rats.
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文献和实验Methods for direct determination of mitomycin C in aqueous solutions and in urine
Stripping voltammetry (SV) is used to quantitatively determine concentrations of the anti-neoplastic drug mitomycin C (MMC) alone and in mixtures with 5-fluorouracil and cisplatin, both of which are used in combined chemotherapy withMMC
MITOMYCIN C TREATMENT OF PMEFs
Cultures to be treated should be sub confluent ie actively growing. 1. Add 1/20 volume Mitomycin C (200 ug/ml 10 ug/ml), to culture and incubate at 37� for 2hrs. 2. After approx. 2 hrs remove medium and collect into a waste bottle
广义的细胞色素 c是含有血红素 c的细胞色素之总称。通常是指主要存在于高等动植物、酵母、霉菌等线粒体中的细胞色素 c，起着传递电子的作用。为分子量约 1.3万的碱性蛋白质，还原型的吸收带为 550、 520、 415毫微米，氧化型为 407毫微米。α 因此很早便被研究，并获得结晶。不仅一级结构而且立体结构也已清楚（图 1）。其结构基本上是生物界共有的。由细胞色素 c氧化酶〔细胞色素（ a＋ a3 ）复合体〕氧化。在呼吸链中从细胞色素 c开始接受电子，各种还原酶都已清楚
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