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- GalNAc
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- 2026年01月02日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 提供商：
湖州河马生物科技有限公司
- 服务名称：
GalNAc合成
- 规格：
5nmol
A more directed approach to the delivery of therapeutic oligonucleotides specifically to the liver has been to target the asialoglycoprotein receptor (ASGPR) using a suitable glycoconjugate. Indeed, ASGPR is the ideal target for delivery of therapeutic oligonucleotides to the liver since it combines tissue specificity, high expression levels and rapid internalization and turnover. The use of oligonucleotide glycoconjugates has led to significant advances in therapeutic delivery as evidenced by the work of Alnylam Pharmaceuticals which has developed multivalent N-acetylgalactosamine (GalNAc) conjugated siRNAs that bind at nanomolar levels to ASGPR.1 A similar strategy has been applied at Ionis Pharmaceuticals directed at the development of antisense oligonucleotide therapeutics.
河马生物科技为您提供GalNAc(GalNAc-siRNA, GalNAc-ASO, GalNAc-microRNA)相关合成产品并为您提供其他复杂修饰，设计
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- 作者
- 内容
- 询问日期
文献和实验(2017).Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates.Nucleic Acids Research,(),.https://doi.org/10.1093/nar/gkx818
(2016).Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice.,(),.https://doi.org/10.1038/mtna.2016.26
(2011).A rapid two-step method for isolation of functional primary mouse hepatocytes: cell characterization and asialoglycoprotein receptor based assay development.Cytotechnology,64(2),187-195.https://doi.org/10.1007/s10616-011-9407-0
Lectin affinity chromatography is a powerful technique for isolation of glycoproteins carrying a specific glycan structure of interest. However, the enormous diversity of glycans present on the cell surface, as well as on individual proteins
会引起凝血酶缺陷，引发血友病，且这种突变是可遗传的。 本项研究中，研究者为了达到促凝血目的，选择抗凝血酶（antithrombin，AT）作为目标设计siRNA药物。AT是一种关键性天然抗凝剂，是凝血酶和FXa最主要的内源性抑制剂，抑制AT可以提升凝血酶水平，促进凝血。 凝血系统示意图本研究针对图中凝血酶（Thrombin）抑制剂AT设计ALN-AT3 基于已有报道，研究者靶向SERPINC1转录本设计了一种携带有GalNac（N
Glycosyltransferases in Chemo-enzymatic Synthesis of Oligosaccharides
the Galα1-3GalNAcβ1-4GlcNAcβ-R (Gal-LDN) moiety, containing the Galα1-3GalNAc epitope found on the parasitic helminth Haemonchus contortus . An acceptor substrate providing a terminal N -acetylglucosamine was prepared by coupling the fluorescent
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