InVivoMab anti-mouse MHC Class

抗原肽锚着残基和MHC分子接纳抗原肽共用基序

抗原肽的锚着残基和 MHC 分子接纳抗原肽的共用基序       抗原肽一般含有2个或2个以上与某个特定MHC分子结合的部位，称为锚着位(anchorposition)，位于该部位上的氨基酸则称为锚着残基。这些锚着残基插入MHC分子抗原结合槽的小袋中，通过氢键与MHC分子相结合。抗原肽中间部位一般均有一定程度的隆起，可作为T细胞表位供TCR识别。     与同一型别MHC分子相结合的不同抗原肽，其锚着位和锚着残基往往相同或相似。进入H-2Kd等位基因分子凹槽

Construction of MHC Class I-Peptide Tetrameric Complexes for Analysis of T-Cell-Mediated Immune Responses

of charge, but for research purpose only (Table 1 ). The construction of MHC class II-peptide tetrameric complexes has proven to be more problematic than class I, with a fewer publications mainly involving mouse tetramers and no standard protocol.

MHC I STREPTAMERS® 检测与分离抗原特异性 (CD8+ T) 细胞

- 001 HIV HLA-A* 0201 HIV- 1 reverse transcriptase ILKEPVHGV 6 - 7005 - 001 Mouse Transgenic mouse OVA model H- 2 Kb Ovalbumin